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- PublicationInnovative Decorative Design Suggestion For Nixi Black Pottery Handicraft At Yunnan, China(2024-10)The Nixi black pottery from Tangdui Village, Shangri-La City, Yunnan Province, China is an intangible cultural heritage with a history of more than 2,000 years. The main problem of Nixi black pottery decoration is the lack of diversified design thinking. The research goal is to propose innovative design suggestions for Nixi black pottery decoration based on the modern aesthetics of the younger generation.
- PublicationThe Impact Of Corporate Moral Hazard On Esg Performance Of The U.S. Mncs: The Interaction Effect Of Type Of Ownership(2024-03)This study analyzes the impact of corporate moral hazard on ESG performance. The study also investigates the interaction effect of the ownership structure on the relationship between corporate moral hazard _ expressed in the gross value and volume of corporate enforcement actions _ and ESG performance.
- PublicationEthanol Extraction, Purification, Antioxidant Properties, And In Vivo Anti-Ageing Effects Of White Tea Flavonoids(2024-10)Based on the differences in qualities, white tea can be divided into four grades: “Shou Mei” (SMT), “Gong Mei” (GMT), “Bai Mu Dan” (White Peony, WPT), and “Bai Hao Yin Zhen” (Silver Needle, SNT). These teas were reported to have various potent bioactivities, such as antioxidant, anti-inflammatory, and anticancer activities. These health functionalities can be traced back to flavonoids found naturally in tea. This study aims to investigate the anti-ageing effects of purified flavonoids from white tea.
- PublicationElucidation Of Circular Rna (Circ007667 And Circ037236) Roles In Colorectal Cancer Pathogenesis(2024-10)Colorectal cancer (CRC) ranks as the third most frequently diagnosed cancer worldwide and the fourth leading cause of cancer-related deaths. Circular RNAs (circRNAs) are unique RNA molecules with a closed-loop structure, lacking 5′ to 3′ polarity and a poly-adenylated tail. Despite their potential, the role of circRNAs in CRC remains poorly understood. This study investigates the roles of circ007667 and circ037236 in CRC, exploring their potential as molecular targets for intervention.
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- ItemProperties Of Recycled Crosslink Polyethylene Filled High Density Polyethylene Composites(Universiti Sains Malaysia, 2013-07)Waste crosslinked polyethylene (XLPE) obtained from a high voltage electric cable was directly utilized, recycled and incorporated into a high density polyethylene matrix. Due to the high gel content (93%), the possibility of producing a completely miscible blend is quite unlikely. However due to that factor, the waste is break down into small filler. They are then compounded with HDPE in concentrations of 5, 10, 15, 20 and 30wt% to produce a composite material. The tensile properties, DSC and morphology of the composite were obtained. However, addition of the waste did not give any reinforcing properties to HDPE matrix. This is visible from the tensile properties of the composite where the tensile strength decreases as the waste concentration increase from 5, 10, 15, 20 and 30%. The elongation at break of the composite decreases as the waste concentration increases from 5, 10, 15, 20 and 30%. The chemical resistance test was done to obtain the tensile properties of before and after immersion. The two chemicals selected are nitric acid and ammonium hydroxide. The tensile strength of the composite decreased compared to virgin HDPE samples. Chemical resistance properties show that overall the tensile strength of the composite decreases with increasing waste concentration from 5, 10, 15, 20 and 30% with chemical concentration of 50 and 100%. For elongation at break of the composite, the value shows irregularity for different waste concentration. Different heating rates of 5, 10 and15°C/min of the DSC scans shows co-crystalization with increasing waste content form 5, 10, 15, 20 and 30%.
- PublicationRational Design And Synthesis Of Peptide Inhibitors Of Ns2b/Ns3 Protease As Therapeutic Agents For Dengue Virus Type 2(2021-10)The main objectives of this study are to design potent and selective peptide inhibitors by studying the interactions between the designed peptides and the NS2B/NS3 dengue protease using two independent docking programs (MOE and AutoDock4.2), thus, to evaluate the quantitative and qualitative docking results from both programs. The other objectives are to synthesize and characterize the potential peptides by using Fmoc Solid Phase Peptide Synthesis (SPPS) technique, to perform NS2B/NS3 dengue protease expression and purification, and finally to investigate the biological evaluation of the selected peptides using in vitro NS2B/NS3 dengue protease inhibition assay.
- ItemDesign And Development Of Robot End-Effector For The Use In Lower-Limb Stroke Rehabilitation Exercises(Universiti Sains Malaysia, 2022-07-25)Stroke is the second largest cause of human death worldwide and is also a major cause of long-term disability such as walking gait abnormalities. Rehabilitation is essential in helping patients regain as much motor function as possible. Robot assisted rehabilitation is currently the forefront in this regard. However, no solutions are currently widely available for use in developing countries like Malaysia. Therefore, there is space for such a product to be developed and commercialized. Thus, a smart lower-limb end-effector prototype that can be installed on a collaborative robot to aid patients performing exercises such as plantarflexion, dorsiflexion, hip abduction and hip adduction was developed. The project kick started by designing the end effector as four different parts on in Solidwork. This step is then followed by slicing process using Ultimaker Cura and then 3D printing. The 3D printed is then assembled up and tested for strength and design accuracy. At this stage, any design failure is then followed by redesigning and 3D printing again. Meanwhile, MPU6050 sensor was coded using Arduino Uno and powered by NodeMcu. This set up was placed on the foot holder to measure the rehabilitation angle. The sensor is also connected any app which was developed using Blynk to showcase the data obtained in terms of angle X˚, Y˚ and Z˚ Then, two healthy subjects, a male and female were choosen to carry out all four type of exercises mentioned above. The results obtained shows that angle recorded falls within the range of a human to carry out those exercise (20-35° of dorsiflexion, 15-30° of plantarflexion, 30–55° of hip abduction and 15–30° of hip adduction). This shows that the end effector perms well and can be used to aid physiotherapist and the patient. Therefore, a smart lower-limb end-effector prototype that can be installed on a collaborative robot to aid patients performing various leg exercises has been successfully created which also incooperates IoT elements.
- ItemRemaining competitive in China: a case study of ACIC's business model on work-integrated -learning(2010-10)This case study explores the strategy engaged by Australia China Investment Corporation (ACIC), taking into account the effects of globalization and the emerging-economy environment of the People’s Republic of China (PRC). ACIC’s business model is based on Work-Integrated-Learning. The Company’s flagship programme, Study Abroad Internship Programme, is chosen as the study object. This case study aims to confirm if the current strategy employed by the company is applicable to remain competitive in the PRC market and further find out the effects of these strategies. The country analysis conducted is PESTLE, based on the framework of Global Competitive Index. SWOT analysis, TOWS matrix with attributes of Balanced Scorecard, and Quality Function Deployment (QFD) concepts together with Sun Tzu Art of Strategy are employed as analysis techniques. It is found that ACIC is employing a combination of strategies and has managed to remain competitive in PRC with an increasing revenue trend. The company focuses on learning and growth as well as its internal processes. Intelligence and information is its utmost priority while positioning, targeting, strength and weakness estimation are also regarded as important. The case study results, while answering the research questions, have also encourage a paradigm shift on defining global business strategy, especially in the dynamic emerging economy of PRC.
- ItemRenal survival and its prognostic factors in chronic kidney disease patients in Hospital Universiti Sains Malaysia, Kelantan(Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia, 2016-04)Introduction: End Stage of Renal Disease (ESRD) in Chronic Kidney Disease (CKD) patients represents a heavy burden for patients, families, and health care systems. Objectives: The objectives of this study were to determine the renal survival time of CKD patients at Hospital USM and to identify the prognostic factors that influence the renal survival of patients. Methodology: A retrospective cohort study was conducted involving 247 CKD patients at Hospital USM, Kelantan from January 2005 until December 2015. All patients who fulfilled the criteria were included in the study. The medical record were reviewed and the renal survival time based on the time of the first date of diagnosis with CKD until the the first date of diagnosis with ESRD or received dialysis. The Kaplan-Meier and Cox proportional hazard regression analyses were used in the statistical analysis. Results: Overall renal survival time of CKD patients was 26 months. The significant prognostic factors that influence the renal survival of CKD patients were GFR (adjusted hazard ratio (HR)=0.96, 95% confidence interval (CI): 0.98,0.99; p value <0.001), smoking status (adjusted HR=2.19, 95% CI: 1.53, 3.13; p value=0.042), comorbid hyperlipidemia (adjusted HR=1.87, 95% CI: 1.34,2.60; p value =0.005), analgesics (adjusted HR=1.87, 95% CI: 1.21,2.88; p value =0.015), functional GI disorder (adjusted HR=1.42, 95% CI:1.07,2.01; p value =0.016), lipid lowering agents (adjusted HR=1.41, 95% CI: 1.02,1.97; p value=0.039), corticosteroid (adjusted HR=2.10, 95% CI: 1.25,3.55; p value =0.005), urea (adjusted HR=1.03, 95% CI: 1.01,1.05; p value <0.001), and creatinine (adjusted HR=0.99, 95% CI: 0.98,1.00; p value =0.005). Conclusion: The medium renal survival time of CKD patients in this study very fast within 26 month. The prognostic factors of renal survival identified were GFR level, smoking status, comorbid hyperlipidemia, analgesics, lipid lowering agents, functional GI disorder, corticosteroid drugs, urea and creatinine are significant to renal survival among CKD patients in Hospital USM. Thus, the clinician can change the clinical management by focus on the factors and slow the progression to ESRD.