Publication: Effect Of Radiotherapy Combined With Capsaicin And Fraxetin As Enhanced Therapy On Colorectal Cancer Cell Line In Vitro
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Date
2025-09
Authors
Hatif, Hatif Abbas Rashid
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Abstract
Colorectal cancer is the second most common cancer in women and third in men, accounting for 9.7 % of all cancers incidence globally, with about 814,000 cases in men and 664,000 cases in women. Colorectal cancer is a disease of ageing where more than 90% occurs in individuals at least 50 years old. For instance, the incidence is 50 times greater in sixty to eighty year olds than in forty year olds or younger. From 1997 to 2004, overall incidence and death due to colorectal cancer decreased by 2.6% and 4.7% respectively. Adjuvant chemotherapy and radiotherapy remain cornerstones in the management of colorectal cancer, in terms of disease-free survival and overall survival benefit. In our study, it was aimed to examine the effects of capsaicin and fraxetin, the active ingredients of chili peppers and fraxinus, which has known anticancer activities, and cisplatin as chemotherapy alone or combination with radiotherapy, on the colorectal cancer cells line and natural human dermal fibroblasts (hdfn). Phytochemicals that can act as antioxidants have been used by people in treatment against cancer throughout human history because of their low toxicity and the ease in availability. Besides providing protection against cancer, they are also found to kill cancer cells. Cells lines were grown in culture in conventional culture flasks in dmem medium at 37 °c and 5% co2. When the cells were 70-80% confluent, morphological changes were examined under an inverted microscope.
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Effect Radiotherapy Combined Capsaicin Fraxetin Enhanced