Publication:
Development Of A Monte Carlo-Based Treatment Planning System For Personalized Dosimetry In Yttrium-90 Hepatic Radioembolization

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Date
2025-07
Authors
Abdul Hadi, Muhammad Fahmi Rizal
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Research Projects
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Abstract
Yttrium-90 (90Y) hepatic radioembolization is a targeted therapy for liver cancer that depends on accurate dosimetry for both treatment efficacy and safety. Conventional dose estimation using the Partition Model (PM) often overlooks patient-specific anatomy and radiation crossfire effects, leading to potential inaccuracies. This study presents a cross-platform treatment planning system (TPS) integrating Monte Carlo (MC) simulations to improve personalised dosimetric evaluation. Pre-treatment CT and 99mTc-MAA SPECT images from patients at University of Malaya Medical Centre were segmented using 3D Slicer to define volumes of interest (VOIs), including lungs, normal liver, and tumour.
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Keywords
Development Of A Monte Carlo-Based Treatment Planning System , Personalized Dosimetry In Yttrium-90 Hepatic Radioembolization
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https://erepo.usm.my/handle/123456789/25063
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Pusat Pengajian Sains Fizik - Tesis