Synthesis, Structural And Antioxidant Studies Of Some Novel Benzofuran And Phthalimide Derivatives
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Date
2018-08
Authors
Then Li Yee
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
In this project, two series of heterocyclic analogues bearing a benzofuran (1a-
1q) and a phthalimide (2a-2g) moieties were synthesized and crystallized. All crystal
structures were revealed by single crystal X-ray crystallography technique, supported
by FT-IR and NMR spectral analysis. The molecular structures and interactions of
these compounds were studied and analysed. Besides, the antioxidant potential of all
compounds were evaluated using different antioxidant assays. In the benzofuran
series, eight of seventeen compounds are assembled in a triclinic š1Ģ
space group, five
in monoclinic P21/n, two in monoclinic C2/c, whereas two in orthorhombic Pna21 and
P212121. The CāC(=O)āCāOāC(=O) connecting bridge of these benzofuran
molecules tends to adopt a nearly perpendicular or a nearly planar conformation.
Intermolecular interactions are most observable in compounds 1f-1k while the least in
compounds 1c and 1n. It was found that compounds 1a, 1d, 1g and 1p were active
towards H2O2 radical scavenging assay, with the incorporation of electron donating
substituents. In the phthalimide series, five from seven compounds adopt a triclinic
š1Ģ
space group while two exhibit monoclinic P21/c and P21/n. Significantly, a Vshaped
configuration is observed in all structures, with respects to their N1āC9āN2
angles. In the molecular packing, most interactions are observed in compound 2f
whereas the least in compound 2d. Based on the inhibition results, it was found that
compounds (2a-2g) are antioxidant inactive.
Description
Keywords
Physics