Characterization Of Superparamagnetic Iron Oxide Nanoparticles With Different Surfactants - In Search Of Optimum Synthesis Parameters For Mri Application
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Date
2018-12
Authors
Salameh Abu Noqta, Osama Ahmad
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
Superparamagnetic iron oxide nanoparticles (SPIONs) have been extensively
studied for various biomedical applications, such as magnetic resonance imaging
(MRI) contrast agents, and hyperthermia. The most common approach used to produce
SPIONs is co-precipitation method. However, problem due to agglomeration and the
broad size distribution of nanoparticles prepared by co-precipitation method hinder
their application progress in MRI. Therefore, this study aims to produce a highly
stabilized and monodispersed SPIONs for MRI contrast agents. In this thesis, SPIONs
were synthesized with different surfactants (tri-sodium citrate, polyvinylpyrrolidone
(PVP), chitosan, cetyl trimethylammonium bromide (CTAB) and citric acid) using the
one pot co-precipitation method for surface modification and to ensure excellent
colloidal stability in water. In addition, the synthesis parameters such as surfactant
concentration, pH, and temperature of reaction were optimized to obtain stabilized
SPIONs. The SPIONs prepared in the presence of tri-sodium citrate formed the most
stable SPIONs due to improved physiological condition, dispersion and stabilization
in aqueous solution. In addition, citrate-SPIONs displayed the highest zeta potential
(ζ= -44.0 mV) and saturation magnetization (Ms=53.9 emu g-1) compared with other
samples, due to the ability of three carboxylate groups dissociated from the citrate to
strongly bind to the surface of SPIONs. The TEM measurements of the different
SPIONs indicated that the type of surfactant affects their average particle sizes and
size distribution. In addition, the presence of defects within the spinel structure, i.e.,
oxidation of the SPIONs, seems to be also influenced by the choice of surfactant.
Description
Keywords
Superparamagnetic Iron Oxide , For Mri Application