Structural analysis of some heterocyclic analogues (Chalcone, pyrazoline, ester and xanthone) and evaluation of their biological potentials
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Date
2016-07
Authors
Loh Wan Sin
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
In this research, four senes of a total of 33 compounds consisting of
chalcone, pyrazoline, phthalimide ester and xanthone heterocyclic analogues were
synthesized and were crystallized. Their molecular structures were elucidated by Xray
diffraction method, using either Bruker SMART APEX II or Bruker APEX II
DUO CCD area-detector diffractometers. It revealed the importance ofsubstituents
on the crystal stability and molecular packing. Subsequently, they were screened for
their biological potentials such as antioxidants, antimicrobial and anticancer.
Chalcone derivatives showed mild to good antioxidant ability. Among them
derivatives with methoxy substituents (-OCH3) at their phenyl rings exhibited the
highest antioxidant activity. Chalcone with halogen sub tituents were te ted for
antimicrobial activity and were found that fluoro substituent at -para po ition of the
phenyl ring showed elevated antimicrobial activity. Pyrazoline derivatives displayed
insignificant activity towards antioxidant and antimicrobial activitie . Phthalimide
ester derivatives were evaluated for their in-vitro antioxidant properties
Description
Keywords
Heterocyclic compounds , xanthone , Bioaccumulation , Structural analysis of some heterocyclic analogues (Chalcone, pyrazoline, ester and xanthone) and evaluation of their biological potentials