Pharmacoeconomic Model Of Dengue Vaccine In Malaysia

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dc.contributor.authorTay, Chai Jian
dc.date.accessioned2019-05-13T01:44:43Z
dc.date.available2019-05-13T01:44:43Z
dc.date.issued2018-07
dc.description.abstractAround two billion people are vulnerable to dengue infections in tropical and subtropical regions, where about 50 to 100 million dengue infections occur each year, leading to 20000 to 30000 deaths annually. Dengue is a mosquito-borne viral disease that is transmitted to humans through the bites of female mosquitoes carrying the virus. Control of dengue epidemic has been elusive, mainly because of the failure to control mosquito breeding habitats in urban environments. Safe, efficacious and cost-effective dengue vaccine is still under testing. The model that links the virus transmission dynamics between mosquito and human is the key to a transparent valuation of dengue vaccine pricing. In this study, an in-house mathematical model named MOSSEIR is developed and used to simulate the dengue transmission dynamics in Shah Alam and Selangor. The dengue transmission dynamics are then examined by deriving the basic reproduction number Ro. Sensitivity analysis for Ro shows that the natural mortality and the biting rate of adult female mosquito are significant parameters in dengue transmission. Control strategies, namely elimination of mosquito breeding sites control, fogging and vaccination, are evaluated by means of the MOSSEIR model. Simulation results indicate that these three control strategies can significantly reduce dengue transmission, in theory. In reality, the effectiveness of traditional control methods such as elimination of mosquito breeding sites and fogging is below expectation due to non-compliance. Therefore, the adoption of a safe, effective and affordable vaccine remains the best prospect for controlling dengue. A pharmacoeconomic model is developed by linking the MOSSEIR model results with the vaccine pricing mechanism to evaluate a highly cost-effective price threshold for Malaysia.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/8190
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectPharmacoeconomic model of dengue vaccineen_US
dc.subjectin Malaysiaen_US
dc.titlePharmacoeconomic Model Of Dengue Vaccine In Malaysiaen_US
dc.typeThesisen_US
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