Fabrication and characterization of alginate microspheres for drug delivery application
| dc.contributor.author | Azfar Syaqir Bin Man | |
| dc.date.accessioned | 2021-02-09T04:05:11Z | |
| dc.date.available | 2021-02-09T04:05:11Z | |
| dc.date.issued | 2019-07 | |
| dc.description.abstract | Drug Delivery Systems (DDS) are engineering technologies for delivery and/or controlling release of therapeutic agents in targeted areas. Microspheres are solid spherical particles ranging in size from 1-1000 μm. Alginate is a naturally occurring polymer found in brown algae. Alginate microspheres are sought after due to its inexpensiveness, nontoxicity, biocompatibility and biodegradability properties. In this study, alginate microspheres will be fabricated via emulsification / gelation technique. Effect of type of oils used soy bean oil, canola oil, palm oil, olive oil (extra virgin) and olive oil (half virgin) and stirring speed (800 rpm, 1000 rpm and 1200 rpm) on the formation of alginate microspheres will be investigated. The obtained alginate microspheres were characterized using scanning electron microscope (SEM) for morphological observation, Fourier Transform Infrared (FTIR), particle size analysis and viscosity testing. SEM observation shows that alginate microspheres were able to formed in all types of oils used. However, the microspheres formed are agglomerated, regardless of stirring speed used. For FTIR, the functional group that had been detected were Hydroxyl (O-H), Carboxylate (C H), Carbonyl (COOˉ) and Ethers (C-O-C). For the particle size analysis, the alginate microspheres of soy bean oil had the smallest particle distribution, 96.20 μm compared to the others. For viscosity testing, soy bean oil had the lowest viscosity, 51.0 cP compared to others. Therefore, it is concluded that lower viscosity oils are better to form alginate microspheres than higher viscosity oils. | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/11208 | |
| dc.language.iso | en | en_US |
| dc.title | Fabrication and characterization of alginate microspheres for drug delivery application | en_US |
| dc.type | Other | en_US |
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