Fabrication and characterization of bioactive glassalginate scaffolds
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Date
2018-06
Authors
Siti Nur Nabilah Mohd Anuar
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Abstract
Tissue engineering evolved from the field of biomaterials development and refers
to the practice of combining scaffolds, cells and biologically active molecules into
functional tissues. The goal of tissue engineering is to assemble functional constructs that
restore, maintain or improve damaged tissues or whole organs. Bioactive glass is one
type of biomaterials where its development has influenced human lives to a large extent
by its versatile medical applications and very promising future. In this present study,
45S5 type of bioactive glass (BG) was used together with mineral cordierite and oxide
cordierite to fabricate scaffolds through freeze drying method. The scaffolds were
fabricated through freeze-drying technique by pre-freezing 20 gram of slurry for each
composition (15 gram 45S5 BG + 5 gram mineral cordierite and 15 gram 45S5 BG + 5
gram oxide cordierite) with subjected pre-freezing temperature; -10'C and -40'C. This
fabrication was fabricated in order to study the effect of mineral and oxide cordierite to
45S5 BG and the effect of different pre-freezing temperature to the mineral cordierite 45S5 and oxide cordierite-45S5 scaffolds. Compression and porosity test were done and
scaffold with 15 gram 45S5 + 5 gram oxide cordierite with -40'C of pre-freezing
temperature give the highest percentage of porosity hence the compression test is the
lowest. The same scaffold was coated with 5 wt.% concentration of sodium alginate to
study the effect of sodium alginate on mechanical properties of the scaffold. Result from
the compression test shows that the strength of the scaffold coated with sodium alginate
is higher compared to the uncoated scaffold with value of 0.037 MPa and 0.01 MPa for
uncoated oxide cordierite-45S5 scaffold with pre-freezing temperature -40'C.