Bioactive glass reinforced polyurethane scaffold- bioactivity and degradation
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Date
2016-06
Authors
Lim Shi Hong
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Abstract
Bioactive and biodegradable scaffold is becoming the better choice for bone implant fixation replacing the bioinert metals and ceramics. Challenges are set by the design and fabrication of synthetic composite scaffold and bioactivity and biodegradation in vitro and in vivo. This study emphasized on the fabrication and investigation on the bioactivity and biodegradation of bioactive glass (BG) reinforced polyurethane (PU) scaffold. Solvent casting/particle leaching technique was utilized and had successfully fabricate the open porous structure scaffold with well dispersed BG particles all around the surface and inner wall of the scaffolds. The scaffolds produced exhibited >80% porosity with open pores of 100 – 400 μm and interconnected micropores of <100 μm which qualified for the bone tissue applications. In vitro experiments have been carried out to investigate the bioactivity and biodegradation of pure PU and PU-BG scaffolds upon immersion in simulated body fluid (SBF). The surface structure, morphology and chemical properties of the scaffolds were evaluated and revealed the formation of hydroxyapatite (HA) layer onto the surface of scaffolds after three days of immersion in SBF. The rapid formation of HA layer indicates the high bioactivity of the composite scaffold. The dissolution of increased Si, Na and Ca and decreased P ions product into SBF solution further confirmed that the BG reacted to form the HA layer.