Evaluation and characterization of NaBH4 treated PLA micrsopheres loaded with gentamicin
| dc.contributor.author | Lim, Chuan Ying | |
| dc.date.accessioned | 2021-08-04T02:53:36Z | |
| dc.date.available | 2021-08-04T02:53:36Z | |
| dc.date.issued | 2016-06 | |
| dc.description.abstract | The emulsion solvent evaporation technique was used to study the encapsulation of gentamicin in PLA microspheres. 0.3 ml of gentamicin was used and encapsulated in PLA microspheres samples. The effects of surface modification by using NaBH4 were studied in this research. The availability of gentamicin also will be evaluated after NaBH4 treatment. The intense peak of gentamicin was expected to be determined by FTIR. It was expected that the surface roughness of treated PLA microspheres to be increased after the modification. It was also expected that the wall thickness of treated PLA microspheres increased as increasing in the concentration of NaBH4 solution. The availability of gentamicin was also calculated through uv-vis characterization. From the FTIR results, it can be concluded that gentamicin had successfully encapsulated in PLA microspheres. FTIR results had shown – NH intense peak which gentamicin had in sample PLA with gentamicin. Besides, increasing in concentration of NaBH4 solution caused the intense peak of – OH groups became broader, showing intensity of hydroxyl group increased. SEM results proved that the surface morphology of PLA microspheres rougher with increased on concentration of NaBH4 solution. From results of contact angle, contact angle decreased as the concentration of NaBH4 solution increased. This is due to the surface hydrophilicity of PLA microspheres also increased as increased the concentration of NaBH4 solution. The improved hydrophilicity was expected to improve the cell-microspheres interactions. The encapsulation efficiency of PLA microspheres was determined by uv-vis test. The results recorded that 12.5 % of gentamicin encapsulated. Therefore, it can be concluded that there was gentamicin encapsulated in PLA microspheres after surface modification. | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/13943 | |
| dc.language.iso | en | en_US |
| dc.title | Evaluation and characterization of NaBH4 treated PLA micrsopheres loaded with gentamicin | en_US |
| dc.type | Other | en_US |
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