Synthesis of Mg-Co-Sr substituted carbonated hydroxyapatite via soft combustion
Loading...
Date
2019-05
Authors
Muhammad Afnan Bin Annuar Samsuri
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Magnesium-cobalt-strontium Carbonated Hydroxyapatite (Mg-Co-Sr CHA) was synthesized via soft combustion method. Soft combustion method were introduced to reduce the cations loss during filtration and wash process in nanoemulsion method. Fuel for soft combustion were varies to get the optimized fuel ratio. Three different fuel ratio to raw materials were use in the synthesis CHA powder. The optimized fuel ratio was 0.25 since it shows better results compared to 0.5 and 0.125 fuel ratio. Magnesium (Mg), Cobalt (Co) and Strontium (Sr) ions were introduced into the apatite structure to improve their mechanical properties and enhance the biological activity which closely mimics to bone mineral. Three different compositions of magnesium (Mg) were synthesize using same technique. CMG 0.60, CMG 0.65 and CMG 0.70 were prepared by using 0.25 fuel ratio. All the samples were calcined at temperature 400 °C. Calcination was done to ensure that is no excess fuel in the samples. The as-calcined CHA and multi-doped CHA were characterized using X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR) and Field Emission Scanning Electron Microscopy (FESEM). All the samples were found to retain as B-type CHA. From XRD results, shows that only HA phase was formed without any secondary phase. The overlapped (211) peak shows the successful carbonate substitution in phosphate cite and broad peak shows the successful doping element substitute in calcium site. The as-calcined multi doped CHA powder were then fabricated by hand hydraulic pressing method to form a 13mm diameter pellet. The pellet use for in vitro bioactivity testing where the samples were soaked into SBF solution for 7 days. CMG 0.70 showed good bioactivity by the fastest formation of apatite layer if compared to other samples. The amount of magnesium, cobalt and strontium in the apatite structure were influenced the bioactivity of the products.