Mathematical modelling of mass transport trough porous media convection-enhanced versus diffusion-limited
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Date
2016-06
Authors
Nur Afiqah Awang Nasran
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Abstract
Mass transport via porous media arises a lot of interest in various engineering field. Tissue Enginnering is one of application of porous media which are aiming to develop the cell to restore, replace and regenerate the defective The component of engineering tissue are commonly cell and scaffold. Scaffolds, typically made of polymeric biomaterials, provide the structural support for cell attachment and subsequent tissue development. However, most of the researchers agree that failure to the three-dimensional tissue engineered constructs at desired sizes were causes of poor nutrient transport. This relates to the design of tissue engineering bioreactors. Hollow fibre membrane bioreactors (HFMBs) are designed to mimic the network of blood vessels to improve nutrient transport capabilities to a better standard. Tissue engineering approach has major advantages over traditional organ transplantation. The nutrient need to supply for the tissue for enhanced the growth and aid in healing process.The scale of cell is too small and it is imposible to monitor the transportation of nutrient. Thus, an approach the mathematical modelling to circumvent the situation. The study of mathematical modeling would give a possible result and simulation of how the concentration of nutrient in HFMB are presented due to the selection of proper parameters needed in tissue engineering applications.