Determination of apparent diffusion coefficient of blood at its various ages using the technique of diffusion mri
| dc.contributor.author | Mohd Taib, Nur Hartini | |
| dc.date.accessioned | 2015-09-03T07:35:57Z | |
| dc.date.available | 2015-09-03T07:35:57Z | |
| dc.date.issued | 2010 | |
| dc.description.abstract | The aim of this study is to develop ADC calibration plot in diffusion MRI and to examine the signal intensity trend of MR-weighted T1-, T2-, proton density and Fluid Attenuated Inversion Recovery images as a function of time ranged from 1 hour to 60 days. Fresh human blood samples were drawn from four volunteers and divided into 3 different categories namely, blood mixed with Citrate-PhosphateDextrose- Adenine (CPDA), blood mixed with thromboplastin and untreated blood as control. A set of T1WI, T2WI, PD, FLAIR and DWI were acquired using 1.0 Tesla MRI system (GE Signa Horizon LX) at Hospital Universiti Sains Malaysia. Measurements of the signal intensity for T1WI, T2WI, PD and FLAIR images were performed using GE ADW 2.0 Software. The reconstruction of the ADC maps and measurement of the ADC values for DWI were carried out using GE ADW 2.0 (Functool) Software. The study demonstrates that there is a significant trend displayed by all types of images. The trend was obviously exhibited in T1 WI, PD and DWI. Generally the curves obtained can be divided into three parts. Firstly, during the first two days in which the signal intensity of all blood categories did not very that much against time. Secondly, significant changes were observed until day 14. Thirdly, from day 14 onwards, reasonably constant values were found. For T2WI and FLAIR images, they did not show a similar trend as of T1WI, PD and DWI but exhibited a new trend which was not seen before. The new trend found in ADC study has the potential of being used as reference to real hemorrhagic situations. The present findings indicate that ADC plot may be used as a general reference in determining the age of blood clot. | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/1159 | |
| dc.language.iso | en | en_US |
| dc.title | Determination of apparent diffusion coefficient of blood at its various ages using the technique of diffusion mri | en_US |
| dc.type | Thesis | en_US |
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