Effect of different molecular weight of chitosan on temperature- and ph- responsive chitosan-starch hydrogel
| dc.contributor.author | Tan Ming Xi | |
| dc.date.accessioned | 2021-02-09T01:45:14Z | |
| dc.date.available | 2021-02-09T01:45:14Z | |
| dc.date.issued | 2019-06 | |
| dc.description.abstract | Nowadays, chitosan has become well-known and commonly applies in biomedical applications. However, the effect of various molecular weight on the properties of chitosan has not been reported yet. Hence, the present study is aimed to fabricate and synthesis different molecular weight of chitosan-starch hydrogel (CSH) by using free radical emulsion polymerization. In the first place, chitosan-starch hydrogels with different molecular weight of chitosan are synthesized. The grades of molecular weight of chitosan include low, medium, high and mix molecular weight while the crosslinker used in this research is glutaraldehyde. After that, seven characterization techniques for examples Field Emission Scanning Electron Microscopy (FESEM), Atomic Force Microscopy (AFM), Fourier Transform Infrared (FTIR), Differential Scanning Calorimetry (DSC), Thermo-gravimetric Analyser (TGA), Equilibrium Swelling Ratio (ESR) and Ultraviolet-Visible Spectroscopy (UVVis) are conducted. From FESEM, chitosan and starch able to form a homogeneous blend and there is no phase separation. Then, AFM images of topography shows by increasing the grade of molecular weight of chitosan, the average roughness of CSH also increasing. However, AFM shows the intertwining of chitosan and starch which indicate these two polysaccharides are compatible. Moreover, FTIR results also prove the synthesis of CSH is successful due to the presence of functional groups of CSH. DSC and TGA graphs also represent the thermal stability of CSH. Next, from the study of swelling behaviour of CSH, the higher the molecular weight of chitosan, the swelling behaviour is getting pronounced, thus ESR also increasing. This is due to polymer- xvii solvent interaction is getting stronger than polymer-polymer interaction. Besides, CSH with higher molecular weight of chitosan has longer fragments, therefore, it is harder for it to protonate the free amino groups. Lastly, from UV-Vis testing, CSH is also responsive to temperature and pH, therefore, CSH are suitable to apply in drug delivery. Overall, chitosan with low molecular weight has the highest compatibility with starch and glutaraldehyde while CSH with high molecular weight of chitosan has the highest ESR. | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/11188 | |
| dc.language.iso | en | en_US |
| dc.title | Effect of different molecular weight of chitosan on temperature- and ph- responsive chitosan-starch hydrogel | en_US |
| dc.type | Other | en_US |
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