Configuration Of Molecular Imprinted Polymers For Specific Uptake Of Pharmaceutical In Aqueous Media Through Radical Polymerization Method
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Date
2021-06-01
Authors
Mohd Amri, Mohammad Hanif
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
Precipitation polymerization method was used to prepare molecularly imprinted
polymers (MIP) for the uptake of acetaminophen in aqueous media. Acetaminophen,
methacrylic acid (MAA), ethylene glycol dimethacrylate (EDGMA), 1,1’-
Azobis (cyclohexanecarbonitrile) (ABCN) were used as template, functional monomer,
cross-linker and intiator respectively. The molarity of cross-linker and functional
monomer were varied for the study of imprinting effect of MIPs. High concentration of
cross-linker exhibit poor binding ability of MIPs while high molarity of monomer
demonstrate better performance in binding capacity. The optimum MIP was observed
from template:monomer:cross-linker molar ratio at 1:58:15 with binding capacity of
3.68 mg/g polymer. Next, pristine PES and molecularly imprinted membrane (MIM)
were fabricated using phase inversion method. MIM was prepared by adding optimum
MIPs in casting solution for the study of antifouling properties as compared to pure
membrane. The relative flux of MIM has showed a poor antifouling behaviour in real
wastewater sample while a good performance in synthetic solution. However, MIM and
pristine membrane have revealed better rejection of acetaminophen in wastewater at
71.31 and 73.06% respectively.