Pluronic F-127 Coated Zinc Oxide Nanoparticles Cytotoxicity And Their Photodynamic Therapy Towards Human Rt4 Urinary Bladder Cancer Cell Lines
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Date
2019-11
Authors
Abdulsalam Ali Soud Abuelsamen
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
Bladder cancer is the most common malignancy of the urinary system and one
of the ten most common cancers that can affect the whole-body. Photodynamic therapy
(PDT) holds promising applications in cancer treatment with high selectivity and
minimum side effects. However, the current clinically approved photosensitizers have
several drawbacks with limited tumour selectivity that affects the healthy normal cells.
Zinc oxide nanoparticles (ZnO NPs) have exhibited promising potential in various
biomedical applications including cancer therapy. In this study, for the first time, the
potential of bare and Pluronic coated ZnO NPs as photosensitizers for effective
photodynamic therapy against bladder cancer RT4 cell line were systematically
investigated. The FESEM and TEM results revealed that Pluronic F-127 coated ZnO
NPs had an average size of 80 nm whereby the Pluronic F-127 coating layer thickness
ranged from 3 nm to 7 nm.
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Keywords
Pluronic F-127 Coated Zinc Oxide Nanoparticles Cytotoxicity , Towards Human Rt4 Urinary Bladder Cancer