Effects Of Camptothecin On Pichia Pastoris Strain Smd1168h Expressing Dna Topoisomerase I On Agar Plates
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Date
2020-07
Authors
Vadiveloo, Sajetra Devi
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
DNA topoisomerase I (TopoI) is a ubiquitous enzyme, that is responsible for releasing topological stress by introducing a temporary nick in one strand of the DNA helix and later, resealing the single-stranded DNA. TopoI is involved in cell proliferation; therefore, overexpression of this enzyme in a cell often mimics cancer cells. Hence, this enzyme plays a major role in molecular biology studies for developing various types of antineoplastic agents, such as camptothecin.
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Keywords
Effects Of Camptothecin , Pichia Pastoris , Smd1168h , Dna Topoisomerase I , Agar Plates