"Synthetic study of C-Arylglycoside"
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Date
2007
Authors
Osman, Dr. Hasnah
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Abstract
The synthesis of C-arylglycoside have attracted much attention due to the stability
towards the enzymatic and acid hydrolysis. In this synthesis, scandium triflate was
used as the Lewis acid to promote~ C-glycosylation reactions. The reaction between
D-olivoside and 2- naphthol was efficiently catalysed by 0.25 equivalents of
scandium triflate with respect to the D-olivoside and afforded a novel 2-hydroxy-1-
[3 ',4' -di-0-acetyl-5 '-methyl-2-deoxy-,8-D-arabino-hexopyranosyl]-naphthalene m
75% yield. The synthesised C-glycoside are characterised by IR, 1H-NMR, and 13CNMR
spectroscopy
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Chemistry