Bioactive glass reinforced polyurethane scaffold- effect of concentration of leaching agent
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Date
2016-06
Authors
Nor Syuhadah Abdul Jaffar
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Abstract
In this study, Polyurethane (PU)-Bioactive Glass (BG) scaffold was prepared using salt leaching technique. PU-BG scaffolds that containing 20 wt% of BG was synthesized with different concentration of leaching agent. NaCl was used as leaching agent with different ratios. The chemical and physical properties of the composites scaffolds were evaluated using different techniques which are Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA), Scanning Electron Microscope (SEM) and porosity was determined. XRD test was carried out on bioglass to confirm that the 45S5 powder was amorphous in nature. The microstructure of the cross-section area and pore size distribution of PU-BG scaffolds were characterized by Scanning Electron Microscopy (SEM). The size of pore depends on concentration and composition of the leaching agent used during fabrication of the scaffolds. The fabricated scaffolds exhibited open pores range between 46 – 398 μm and interconnected pore of 10 – 89 μm in size. SEM analysis shows that ratio PU : NaCl / 1 : 7 scaffold shows the highest pore size and porosity among PU-BG scaffolds and with the pore size and porosity obtained for all scaffolds satisfied the requirements for bone tissue engineering applications.