Pusat Penyelidikan Dadah dan Ubat-Ubatan - Tesis

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Studies Of Behaviour, Hippocampal Plasticity And Molecular Pathways In A Ketamine-Based Model Of Schizophrenia
(2025-05)
Abdullah, Muhammad Hazim
Schizophrenia is a complex, chronic and relapsing mental health disorder that presents with positive, negative and cognitive symptoms. Ketamine, a non-competitive antagonist for the n-methyl, d-aspartate (nmda) receptor was suggested to be a suitable drug for developing psychotic activities due to its strong psychotomimetic properties as well as reduced level of neurotoxicity compared to previously used medications for developing schizophrenia model. However, there are gaps that need to be filled to develop a good model of schizophrenia using ketamine such as the optimum doses and duration required as well as the range of the effects on the schizophrenia-like symptoms in the animal model. The study aimed to characterise the behavioural, hippocampal neuroplasticity and molecular pathways in different doses of the ketamine-induced schizophrenia model. Different doses of ketamine (10, 50 and 100 mg/kg) were administered to the rats to develop a schizophrenia model via intraperitoneal (i.P). For 10 days. To assess the effects of ketamine on schizophrenia-like symptoms in the animal model, several behavioural studies were performed. The effects of ketamine on positive symptoms can be represented by hyperagitation and hyperactivity which were studied by measuring the locomotor activities using an open-field test (oft).