Pusat Penyelidikan Dadah dan Ubat-Ubatan - Tesis

Browse

Recent Submissions

Now showing 1 - 5 of 78
  • Thumbnail Image
    Publication
    Studies Of Behaviour, Hippocampal Plasticity And Molecular Pathways In A Ketamine-Based Model Of Schizophrenia
    (2025-05)
    Abdullah, Muhammad Hazim
    Schizophrenia is a complex, chronic and relapsing mental health disorder that presents with positive, negative and cognitive symptoms. Ketamine, a non-competitive antagonist for the n-methyl, d-aspartate (nmda) receptor was suggested to be a suitable drug for developing psychotic activities due to its strong psychotomimetic properties as well as reduced level of neurotoxicity compared to previously used medications for developing schizophrenia model. However, there are gaps that need to be filled to develop a good model of schizophrenia using ketamine such as the optimum doses and duration required as well as the range of the effects on the schizophrenia-like symptoms in the animal model. The study aimed to characterise the behavioural, hippocampal neuroplasticity and molecular pathways in different doses of the ketamine-induced schizophrenia model. Different doses of ketamine (10, 50 and 100 mg/kg) were administered to the rats to develop a schizophrenia model via intraperitoneal (i.P). For 10 days. To assess the effects of ketamine on schizophrenia-like symptoms in the animal model, several behavioural studies were performed. The effects of ketamine on positive symptoms can be represented by hyperagitation and hyperactivity which were studied by measuring the locomotor activities using an open-field test (oft).
  • Thumbnail Image
    Publication
    Discovery Of Multi-Targeting Inhibitors In Parkinson’S Disease Using Molecular Modelling, In Silico Admet Profiling, And Behavioural Analysis Of Zebrafish Larvae
    (2025-01)
    Yahaya, Sani Najib
    Parkinson's disease (pd) is a neurodegenerative disorder that usually leads to physical disability. This research aims to identify inhibitors targeting multi-target proteins involved in the progression of pd. Ligand-based pharmacophore models (lbp) were developed and validated using α-synuclein (α-syn) protein and prolyl oligopeptidase (pop) enzyme inhibitors. Lbp model-3 for α-syn and model-2 for pop inhibitors were selected based on the gunner henry score and enrichment factor techniques. These models were employed for the screening of potential pd inhibitors. The α-syn model-3 has pharmacophoric properties consisting of 4 hydrogen bond acceptors, 5 hydrogen bond donors and 1 aromatic ring and is used to screen the maybridge, ibs, and arsinex databases, which in total have 254,870 compounds. The pop model-2, on the other hand, features 1 hydrophobic group, 1 positive ionized group, and 2 aromatic rings and is used to screen the ibs database, which consists of 69,543 compounds. Model-3 and model-2, respectively, managed to identify 281 and 177 compounds through the virtual screenings.
  • Thumbnail Image
    Publication
    Design, Synthesis And Biological Evaluation Of New Opioid Analgesics Based On Tetrahydro-Β-Carboline Scaffold In Zebrafish (Danio Rerio) Larvae
    (2024-03)
    Alananzeh, Waleed Abdullah Ahmad
    The present study aims to design, synthesise, and evaluate the analgesic activities of THβC derivatives. A database of 25,227 THβC analogues was prepared from structure based virtual screening of the ZINC database for bromine fragments and linking the fragments at the N2 position of the THβC scaffold.
  • Thumbnail Image
    Publication
    The Effect Of Mitragynine Addiction In Rats On Histone Regulations And Neuroplasticity
    (2024-01)
    Suleiman, Yunusa
    Mitragynine (MIT) was reported to develop addiction and impair cognitive functions. In acute studies, MIT was found to disrupt hippocampal synaptic transmission and distort memory via unknown mechanisms. This project evaluated the impact of 14 days of MIT exposure on the modulation of histone, synaptic transmission, and its potential mechanisms as well as dopaminergic, GABAergic, cholinergic, and glutamatergic systems in the rats’ brains. The impact of pharmacological inhibition of histone deacetylase enzyme on MIT action was also evaluated.
  • Thumbnail Image
    Publication
    Determination Of Haematological And Endogenous Steroids Profiles In Malaysian Junior Athletes
    (2019-04)
    Mohd Rodhi, Ainolsyakira
    Haematological and steroidological profiles have been used by World Anti-Doping Agency (WADA) to monitor the use of banned substances among athletes. These profiles can be highly influenced by many factors such as gender, physical activity, dietary, geographical factors and genetic origins. Establishing reference values of steroids and haematology profile in laboratory could be beneficial as it can compensate for the difference in local athletes. The aims of this study were to establish haematological and steroidological reference values for local athletes and to compare the variation of these values on several subpopulations. Blood and urine samples were collected from 126 athlete and 39 non-athlete subjects from three major ethnic groups within five consecutive weeks.