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Optimizing The Production Of Short-Peptide Tagged Ss3A Recombinant Protein As A Potential Serological Biomarker For Strongyloidiasis
(2023-02)
Hassan, Nur Hassanah Mohd
Strongyloides stercoralis is a human-pathogenic nematode with a unique ability to autoinfect causing a parasitic disease called strongyloidiasis. Although listed as one of the neglected tropical diseases by World Health Organisation (WHO), the infection has a worldwide distribution with approximately 613.9 million cases mostly in tropical countries. Human infection occurs when the infective filariform S. stercoralis larvae in contaminated soil penetrate the intact skin through direct contact, travel to the mouth through bloodstream before it gets swallowed and resides in the gut. In the gut, female adult larvae produce eggs parthenogenetically, continuing their life cycle without having to leave the host’s body through a process called autoinfection. In general, the post-infection symptoms vary in two different ways. In immunocompetent individuals, hosts usually exhibit minimal to no symptoms (asymptomatic) and causes a life-long infection whereas in immunosuppressed individuals, unchecked infection is highly inclinative towards developing hyperinfection syndrome, an event where the larvae over-proliferate and disseminate to organs including the lung, liver, and brain.