Pusat Pengajian Sains Kimia - Tesis

Browse

Browsing Pusat Pengajian Sains Kimia - Tesis by Subject "Anti-Diabetic Activity Chemical Constituents Isolated Kopsia"

Now showing 1 - 1 of 1
  • Thumbnail Image
    Publication
    Anti-Diabetic Activity Of Chemical Constituents Isolated From Kopsia Teoi And Catharanthus Roseus (Apocynaceae), And Corrosion Inhibition Studies Of Its Extracts
    (2025-05)
    Jaf, Muhammad Tahir Muhammad Al
    This research involved extracting dried ground bark from kopsia teoi (k. Teoi) and catharanthus roseus (c. Roseus) using n-hexane, dichloromethane (dcm), and methanol (meoh) solvents to produce the crude extracts. Alkaloids were isolated from dragendorff-positive dcm extracts via acid-base extraction with hcl and nh4oh, yielding a dcm alkaloid extract. Fractionation by cc and analysis by tlc led to further purification, isolating alkaloids. From k. Teoi, ten compounds were isolated, including four new compounds: 16-epi-deacetylakuammiline n(4)-methylene chloride (602), n(1)-methoxycarbonyl-11-methoxy-12-hydroxy-δ14‒17-kopsinine (603), n(1)-methoxycarbonyl-11,12-methylenedioxy-δ14‒17-kopsinine (604), and n(4)-hydroxymethyl-kopsinine (605). Additionally, known compounds were isolated, including leuconolam (301), kopsiloscine g (413), e-akuammidine (132), n(1)-methoxycarbonyl-12-methoxy-δ16,17-kopsinine (302), kopsininate (312), and n(1)-methoxycarbonyl-11,12-methylenedioxy-δ16,17-kopsinine (383). Meanwhile, from c. Roseus, five compounds were isolated, including one new compound: 16-epi-deacetylakuammiline-7-methyl-n(4)-methylene chloride (606), and four known compounds, namely: β-amyrin (590), ursolic acid (591), dodecanoic acid (596), and oleic acid (598). The isolated compounds were characterised using ft-ir (atr), 1d- and 2d- nmr, uv spectroscopy, and high-resolution electrospray ionisation mass spectroscopy (hresims), with comparison to literatures data.