Pusat Pengajian Sains Kimia - Tesis

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    Design, Synthesis, In Silico And In Vitro Evaluations Of New Inhibitors Targeting Human Hypoxia Inducible Factor (Hif) Prolyl Hydroxylase Domain (Phd) Enzymes
    (2025-09)
    Mohammad, Sayaf Abrar
    Hypoxia inducible factor (HIF) prolyl hydroxylase domain (PHD) enzymes play a pivotal role in oxygen sensing and regulation, making them key therapeutic targets for hypoxia-related diseases, including cardiovascular diseases (CVDs), chronic kidney disease (CKD), and anemia. However, current PHD inhibitors suffer from significant limitations, including toxicity, thromboembolic risks, and poor selectivity, necessitating the discovery of safer and more effective alternatives. This research utilises a computational-experimental methodology to discover new PHD inhibitors through the integration of molecular docking, molecular dynamics (MD) simulations, and free energy calculations, QSAR modeling, and experimental validation.
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    Ferrite-Based Oxides: Preparation, Characterization And Carbon Dioxide Adsorption Study
    (2025-09)
    Sulaiman, Nur Izzana
    In response to the growing demand for effective carbon capture technologies, this study investigates the synthesis and characterization of ferrite–based oxides solid adsorbents prepared using a facile sol-gel method. The primary aim is to enhance the adsorption capacity, reusability and structural properties of the adsorbent. Besides, ternary and quaternary ferrite–based oxides have seen limited exploration in the field of carbon capture, largely due to the prevalence of studies focusing on simpler single metal oxides. These complex multi-metal systems offer the potential for enhanced CO2 adsorption properties yet remain underutilized. In this study, inverse spinel ferrite along with M-type and W-type hexaferrite adsorbents, were successfully synthesized using low-cost, facile and efficient method.
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    Development Of Polyvinyl Alcohol/ Microcrystalline Cellulose/ Anthocyanin Biofilm As Ph-Sensitive Indicator For Smart Packaging
    (2025-09)
    Mohd Nor Azam, Nur Adriana
    Recent studies have highlighted the negative environmental effects of petroleum-based plastics, emphasizing the increasing demand for biodegradable and smart food packaging materials. A sustainable and pH-sensitive food packaging film based on polyvinyl alcohol (PVA, 8%), microcrystalline cellulose (MCC, 2%), and anthocyanin (9% w/w) was developed using a solvent casting method in this study.
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    Bismuth Oxybromide-Based Composites Integrated Biochar From Palm Oil Mill Effluent Sludge For Photocatalytic Remediation Of Ciprofloxacin In Aqueous Medium
    (2025-09)
    Abdul-Raheem, Maryam Nike
    Bismuth oxybromide (BiOBr) is a promising semiconductor with a narrow band gap (~2.7–2.9 eV), making it an attractive photocatalyst for various applications. However, its practical use is limited by low surface area, high electron-hole recombination rate, restricted visible light absorption, and difficulty in reuse. This study addresses these issues by developing BiOBr-based composite systems with enhanced photocatalytic performance for the treatment of pharmaceutical wastewater, using ciprofloxacin (CIP) as a model contaminant. A sustainable BiOBr-biochar composite (BBC) was synthesized via a solvent-free hydrothermal method using biochar derived from palm oil mill effluent sludge (POMES) as a support matrix.
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    Kinetics Improvement Of Lithium Aluminium Hydride And 9- Ethylcarbazole Complex For Hydrogen Storage
    (2025-08)
    Liu, Huilin
    Hydrogen storage remains a critical bottleneck in the realization of a sustainable hydrogen economy. Lithium aluminum hydride (LiAlH4) and 9- ethylcarbazole (NCZ) are two promising hydrogen storage materials due to their high theoretical hydrogen capacities. However, their practical applications are limited by the poor reversibility of LiAlH4 and the sluggish (de)hydrogenation kinetics of NCZ. In this work, a novel composite system composed of LiAlH4 and NCZ in a 1:1 molar ratio (denoted as LA–NCZ) was synthesized and investigated. The composite exhibited a synergistic enhancement in hydrogen storage behavior: NCZ significantly reduced the dehydrogenation temperature of LiAlH4, enabling rapid dehydrogenation in a narrow temperature window between 150 °C and 160 °C. Differential scanning calorimetry (DSC) revealed dehydrogenation peaks at lower temperatures compared to pristine LiAlH4, and Kissinger analysis yielded significantly reduced apparent activation energies of 36.76 ± 1.33 kJ/mol and 83.11 ± 2.87 kJ/mol for the first and second steps, respectively. Interestingly, the dehydrogenation products of LiAlH4 (LiH and Al) further promoted the hydrogenation rate and selectivity of NCZ, achieving a hydrogen uptake of 5.6 wt% under 90 °C and 70 bar H2 with 5 wt% Ru catalyst, close to the theoretical value of fully hydrogenated NCZ.