Pusat Pengajian Sains Kimia - Tesis
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- PublicationSynthesis, Characterization, Mesomorphic Properties And Molecular Model Study Of Non-Linear Disulphide Centred Liquid Crystal Oligomers(2025-02)Yap, Pui WingThree series of non-linear disulphide centred liquid crystal oligomers, namely azo-ss-n, sb-ss-n and e-sb-ss-n were successfully synthesized and characterized. Azo-ss-n has azo unit (n=n) and no lateral substituent whereas sb-ss-n and e-sb-ss-n have azomethine (hc=n) and respective lateral substituents. The structural elucidation of the compounds was based on the spectroscopic methods such as chn, ft-ir, 1d and 2d-nmr and uv-vis whereas their optical texture and thermal behaviours were analysed by pom and dsc, respectively. All three series are predominantly monotropic nematogen. In the photoisomerization study, azo-ss-n has high ce values (>80.00 %) whereas sb-ss-n and e-sb-ss-n have moderate ce values (>40.00 %). Though, three series showed long duration of thermal back relaxation which suggested their potential in the creation of optical storage devices. Mm2 calculation is conducted to obtain the molecular conformation, molecular length and breadth, aspect ratio and c-s-s-c torsion angle.
- PublicationSynthesis Of Carboxamidostilbene Analogues Via Heck-Cross Coupling Reaction, In Silico And Antidiabetes Evaluation(2025-02)Babai, MahdiNew series of ortho-carboxamidostilbene and para-carboxamidostilbene derivatives were synthesised via the heck coupling reaction. The structures of the synthesised compounds were confirmed by various spectroscopic analyses, including ftir, hresims, 1d-nmr (1h nmr and 13c nmr), 2d-nmr (cosy and hmbc). Carboxamidostilbenes were synthesised by reacting iodophenyl acylamide in dry dmf with styrene and et3n as the base in the presence of palladium (ii) acetate (pd(oac)2). All carboxamidostilbenes were screened in vitro for their α-amylase inhibition properties, using resveratrol and acarbose as referenced drugs. The compounds exhibited moderate to good inhibitory activity, with ic50 values ranging from 13.3 to 28.2 μm, compared to resveratrol and acarbose (ic50 = 35.0 ± 3.5, 30.2 ± 0.1 μm, respectively). Among them, compounds 186e, 186f, 187e, 191d, 191e, 191f, 192c, 192d, 192e and 192f showed significant α-amylase inhibitory activity, with ic50 values between 13.3 and 27.9 μm. Structure-activity relationship (sar) analysis was performed to establish the relationship between chemical structure and α-amylase inhibitory activity. In silico molecular docking was used to model the binding interactions of the ortho- and para-carboxamidostilbenes with α-amylase. Pharmacokinetic properties (adme) and drug-likeness were also investigated. Molecular docking studies showed strong interactions between the investigated molecules and the α-amylase binding pocket.
- PublicationSynthesis, Characterization, And Photocatalytic Degradation Activities Of Tio2/Go And Zno/Go In Aqueous Medium(2025-07)Jamjoum, Hayfa Alajilani AbraheemThis research covers the preparation of TiO2 and ZnO photocatalysts using environmental friendly methods that involved the use of lime peel extract as a reducing and capping agent.
- PublicationPenggunaan Natrium Glukonat Sebagai Agen Pengkompleks Dalam Proses Penyaduran Tanpa Elektrik Kuprum(1996-12)Zakaria, HaslizaidiKajian tentang penggunaan natrium glukonat sebagai agen pengkompleks dalam larutan penyaduran tanpa elektrik kuprum bagi pelaplsan kuprum ke atas plastik akrilonitril butadiena stirena (ass) telah dijalankan. Pengkompleks asid etilena diamina tetraasetik (edta) dan natrium kalium tartrat telah digunakan sebagai perbandingan terhadap glukonat. Kajian beberapa gabungan glukonat-edta dengan nisbah kompleks glukonat-edta 1 :1, 1:2 dan 2:1 juga dilakukan untuk mengetahui kesannya terhadap kestabilan, ph, kadar pelapisan, suhu dan kepekatan komponen aktif. Didapati penggunaan pengkompleks glulmnat-edta (1 :1) [komposisi larutan terdiri daripada kuprum sulfat 5-hidrat sebanyak 8.0 gil, natrium glukonat -. Sebanyak 3.5 gil, edta sebanyak 6.0 gil, formaldehida (37 ok) sebanyak 90.0 mill dan natrium hidroksida sebanyak 10.0 gil] adalah lebih stabil berbanding dengan larutan yang hanya mengandungi pengkompleks glukonat sahaja [komposisi larutannya terdiri daripada kuprum sulfat 5-hidrat sebanyak 8.0 gil, natrium glukonat sebanyak 7.0 g/l, formaldehida (37 o..{,) sebanyak 90.0 mill dan natrium hidroksida sebanyak 10.0 gil]. Larutan penyaduran tanpa elektrik kuprum yang menggunakan penqkornpleks tartrat paling tidak stabil. Keadaan operasi yang optimum bagi pengkompleks glukonat ialah ph antara 12.4-12.6 dan pada suhu bilik. Kadar pelapisan bagi larutan menggunakan pengkompleks glukonat adalah paling perlahan manakala kadar pelapisan bagi pengkompleks edta yang paling cepat.
- PublicationPreparation Of Pani/Go/Mof-Fe3o4 Nanocomposite Via Sol-Gel Method For Removal Methyl Orange And Naproxen Sodium(2025-06)Hussain, EjazDischarging industrial dyes and emerging contaminants (ECs) into water resources has become a severe ecological and public health hazard, evidenced by measurable contaminant levels in wastewater and their adverse impacts on aquatic life and human health. In this study, a simple synthesis method (in-situ polymerization) has been employed to synthesize PANI/GO/MOF-Fe3O4 nanocomposite for the adsorption of industrial dye: methyl orange (MO) and an emerging contaminant, naproxen sodium (NAP), from the wastewater.