Pusat Pengajian Sains Kimia - Tesis
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- PublicationSynthesis, Characterization And Photocatalytic Activity Of Go/Zno/Ag Composite For The Imidacloprid Degradation(2025-06)Afridi, Saima KhanIn this study, a ternary nanocomposite (GO/ZnO/Ag) i.e., a graphene oxide (GO) interfaced, zinc oxide (ZnO) photocatalyst, doped with silver (Ag) is synthesized for imidacloprid (IMD) degradation. For GO synthesis, Oil Palm Empty Fruit Bunch Fiber (OPEFB) was used as its precursor for graphite preparation.
- PublicationEvaluation Of Antidiabetic Activity Of Christia vespertilionis (BAKH.F.) Leaves Extract Using Metabolomics Approach(2025-06)Selvarajoo, PuvanadeviThis study investigates the antidiabetic potential of C. vespertilionis leaves through an integrated approach combining in vitro and in vivo metabolomics with molecular docking simulations. This study has demonstrated the antidiabetic potential of C. vespertilionis leaves through comprehensive in vitro, in vivo, and in silico investigations with the aid of the metabolomics approach.
- PublicationInnovative Strategies For Rubberwood Preservation: Tebuconazole Loaded Formulations Via Nanoprecipitation And Self-Emulsifying Drug Delivery Systems(2025-06)Ong, ZhexunWood preservation is important in protecting wood from deterioration, and new technology has emerged to improve current preservative delivery and solubility under the vacuum pressure system. In this research, tebuconazole-loaded zein nanoparticles (TEB-zein nanoparticles) and tebuconazole-loaded self-emulsifying drug delivery system (TEB-loaded SEDDS) were synthesised.
- PublicationSynthesis, Characterization, Mesomorphic Properties And Molecular Model Study Of Non-Linear Disulphide Centred Liquid Crystal Oligomers(2025-02)Yap, Pui WingThree series of non-linear disulphide centred liquid crystal oligomers, namely azo-ss-n, sb-ss-n and e-sb-ss-n were successfully synthesized and characterized. Azo-ss-n has azo unit (n=n) and no lateral substituent whereas sb-ss-n and e-sb-ss-n have azomethine (hc=n) and respective lateral substituents. The structural elucidation of the compounds was based on the spectroscopic methods such as chn, ft-ir, 1d and 2d-nmr and uv-vis whereas their optical texture and thermal behaviours were analysed by pom and dsc, respectively. All three series are predominantly monotropic nematogen. In the photoisomerization study, azo-ss-n has high ce values (>80.00 %) whereas sb-ss-n and e-sb-ss-n have moderate ce values (>40.00 %). Though, three series showed long duration of thermal back relaxation which suggested their potential in the creation of optical storage devices. Mm2 calculation is conducted to obtain the molecular conformation, molecular length and breadth, aspect ratio and c-s-s-c torsion angle.
- PublicationSynthesis Of Carboxamidostilbene Analogues Via Heck-Cross Coupling Reaction, In Silico And Antidiabetes Evaluation(2025-02)Babai, MahdiNew series of ortho-carboxamidostilbene and para-carboxamidostilbene derivatives were synthesised via the heck coupling reaction. The structures of the synthesised compounds were confirmed by various spectroscopic analyses, including ftir, hresims, 1d-nmr (1h nmr and 13c nmr), 2d-nmr (cosy and hmbc). Carboxamidostilbenes were synthesised by reacting iodophenyl acylamide in dry dmf with styrene and et3n as the base in the presence of palladium (ii) acetate (pd(oac)2). All carboxamidostilbenes were screened in vitro for their α-amylase inhibition properties, using resveratrol and acarbose as referenced drugs. The compounds exhibited moderate to good inhibitory activity, with ic50 values ranging from 13.3 to 28.2 μm, compared to resveratrol and acarbose (ic50 = 35.0 ± 3.5, 30.2 ± 0.1 μm, respectively). Among them, compounds 186e, 186f, 187e, 191d, 191e, 191f, 192c, 192d, 192e and 192f showed significant α-amylase inhibitory activity, with ic50 values between 13.3 and 27.9 μm. Structure-activity relationship (sar) analysis was performed to establish the relationship between chemical structure and α-amylase inhibitory activity. In silico molecular docking was used to model the binding interactions of the ortho- and para-carboxamidostilbenes with α-amylase. Pharmacokinetic properties (adme) and drug-likeness were also investigated. Molecular docking studies showed strong interactions between the investigated molecules and the α-amylase binding pocket.