Pusat Racun Negara - Tesis

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    Assessing Knowledge, Attitudes, And Practices Regarding Antibiotic Use And Resistance: A Comprehensive Study Among Private Primary Care Providers And The Public In Northern Malaysia
    (2024-11)
    Sathasivan, Deebadarishani
    Antimicrobial resistance (amr) is considered a global health threat by the who, and unfortunately malaysia, like every other country in the world, is not immune to this danger. Studies have shown that antibiotic prescribing among primary care in malaysia is much higher in private clinics than in public clinics, and that knowledge of antibiotics among general practitioners is only moderate. This is of particular concern as the inappropriate use of antibiotics leads to antibiotic resistance in humans and subsequently has been shown to be fatal. Primary health care providers are responsible for prescribing and dispensing antibiotics to patients for various health indications. Therefore, they play an important role in ensuring the correct use of antibiotics among the public, parallel with government efforts to prevent amr. This study was conducted to fill the gaps of knowledge, attitudes and practices among healthcare providers in the private sector and the public. A cross-sectional survey using self-completed questionnaires was conducted among three different study populations of general practitioners, pharmacists and the general public in the northern states of malaysia, including perlis, kedah, pulau pinang and perak. This descriptive research was conducted during the new norm of the covid-19 pandemic.
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    Risk Assessment Of 2- And 3-Monochloropropanediol And Glycidol Fatty Acid Esters In Selected Food And Infant Formula In Malaysia
    (2024-02)
    Nik Azmi, Nik Nur Ashirah
    The study aims to determine the presence of MCPDEs and GE in specific food samples and infant formula and then estimate the risk to the adult population and newborns.
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    Development And Effectiveness Of Mass Media Education Campaign On The Knowledge, Beliefs, Attitudes And Behaviour Relating To Qat Chewing And Health Risk Among Secondary School Students In Aden, Yemen
    (Universiti Sains Malaysia, 2017-10)
    Al-Kaf, Mohammed Saleh Ahmed
    Qat (Catha edulis) is a species belonging to the plant family Celastraceae. Qat is commonly chewed throughout East Africa and the Arabian Peninsula since the 11th centuryThe fresh leaves and buds of the plant contain cathinone and cathine as the active substances. Cathinone is an amphetamine like stimulant responsible for most of its pharmacological action. Among them, is enhancing concentration, and this has been used as a reason for the students to consume qat. A cross-sectional study was carried out aimed at determining the prevalence of qat chewing among adolescents followed by a pre-test post-test experimental control design study aimed at evaluating the outcome of mass media educational campaign on the knowledge, beliefs, attitudes and behavior of qat chewing health risk among public secondary school students in Aden city, Yemen.
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    Development and evaluation of docetaxel encapsulated nanoparticles from poly(3-hydroxybutyrate-CO-4-hydroxybutyrate) biopolymer.
    (Universiti Sains Malaysia, 2012-10)
    Fisol, Faisalina Ahmad
    Tiga jenis nanopartikel (NPs) yang mengandungi drug antikanser yang kurang larut air iaitu docetaxel (DCX), telah dibangunkan projek penyelidikan ini menggunakan polimer terbiodegradasi poli 3-hidroksibutirat-ko-4-hidroksibutirat [P (3HB-ko-4HB)]. Three types of nanoparticles (NPs) loaded with poorly water soluble anticancer drug, docetaxel (DCX), were developed in this research using poly 3-hydroxybutyrate-co-4-hydroxybutyrate P(3HB-co-4HB) biodegradable polymers.
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    Clinical And Toxicological Aspects Associated With Paracetamol Poisoning And Predictors Of Its Outcomes
    (2011-12)
    Zyoud, Sa'ed H. A.
    Paracetamol is a common source of poisoning, and early identification of patients with more severe poisoning is the key to improving outcomes. Many aspects of paracetamol toxicity and treatment remain poorly understood. To improve knowledge about paracetamol poisoning, the current 5-year, hospital-based study was carried out with the following primary objectives (1) to determine the pattern of paracetamol poisoning among patients who were admitted to Hospital Pulau Pinang (HPP); and (2) to identify indicators of poor prognosis at first hospital presentation for improving clinical care and determining intervention targets for prevention, early detection, diagnosis and treatment. This is an observational retrospective cohort study of hospital admissions for acute paracetamol poisoning between 1 January 2004 and 31 December 2008. Overall, 305 patients met the inclusion criteria. Gastrointestinal (GI) manifestations were common in patients who reported ingestion of ≥ 8 g of paracetamol, and whose latency was longer than 8 hours; and both of these factors were identified as strong independent predictors of the presence of GI manifestations, especially nausea/vomiting. The presence of GI symptoms was a significant marker of poor outcomes and increased hospital stays. Additionally, hypokalaemia is highly associated with paracetamol poisoning.