Publication: Characterization and properties of electrospun polycaprolactone polyethylene oxide/bioglass scaffold for guided bone regeneration
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Date
2024-08-01
Authors
Mohamed Ali, Ehmoda Ali
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Abstract
Guided Tissue/Bone Regeneration (GTR/GBR) is an established dental
technique that promotes damaged bone and tissue regrowth. This method utilizes guide
materials that are biodegradable over time, allowing for the integration of new tissue.
GTR/GBR scaffolds must satisfy several criteria for optimal efficacy, including
biocompatibility, appropriate mechanical properties such as rigidity and elasticity,
porosity, and clinical practicality. In pursuit of these requirements, this study explores
the synthesis of scaffolds by blending polycaprolactone (PCL) with polyethylene
oxide (PEO) and bioactive glass (BG) through electrospinning. Initially, PCL was
dissolved in a solvent mixture comprising acetic and formic acids at a 3:7 volume ratio.
The research then focused on evaluating the influence of electrospinning parameters
and PCL concentrations on fiber morphology. It was observed that scaffolds with a
20% PCL concentration demonstrated enhanced properties relative to other
concentrations. Furthermore, the addition of PEO and BG was explored. The
introduction of PEO at various blend ratios markedly affected the scaffold's
mechanical properties, with the PCL/PEO (90/10) blend showing improved
mechanical strength. The incorporation of BG was shown to enhance surface
roughness and hydrophilicity. Moreover, in vitro assessments indicated that scaffolds
containing BG facilitated hydroxyapatite formation. However, increasing BG content
slightly reduced mechanical properties compared to the PCL/PEO (90/10) scaffolds.
The optimal composition was PCL/PEO -BG7%, which exhibited a balanced performance in the GBR requirements. The in vitro cell study also showed that the
scaffolds with BG enhanced the proliferation of SaOS-2 cells. The study suggests that
PCL/PEO/BG electrospun scaffolds have potential applications in GBR.