Publication: Pharmacogenetic And Molecular Docking Analysis Of Hla-A, -B, And -Drb1 Markers In Antiepileptic Drug-Induced Severe Cutaneous Adverse Reactions In The Iraqi Population
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Date
2025-09
Authors
Ahmed, Ali Fadhel Ahmed
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Abstract
Severe Cutaneous Adverse Reactions (SCARs) induced by antiepileptic drugs (AEDs) are life-threatening immune-mediated conditions that present significant clinical challenges. Pharmacogenetics, particularly the study of human leukocyte antigens (HLA), plays a crucial role in predicting susceptibility to SCARs and guiding precision treatment strategies. This study focuses on identifying HLA alleles associated with AED-induced SCARs in the Iraqi population, particularly those linked to carbamazepine (CBZ), phenytoin (PHT), and lamotrigine (LTG). This study aims to determine the allele frequencies of HLA-A, HLA-B, and HLA-DRB1 gene variations in healthy individuals, examine the clinical characteristics and types of SCARs, evaluate the correlation between HLA genotypes and susceptibility to SCARs by comparing affected cases and control group, and explore the mechanistic basis of these reactions through molecular docking of the implicated HLA alleles.
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Keywords
Pharmacogenetic And Molecular Docking Analysis Of Hla-A , -B , And -Drb1 Markers , Antiepileptic Drug-Induced Severe Cutaneous Adverse Reactions , Iraqi Population