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Synthesis Of Blood-Brain Barrier Permeable Aurones As Modulators Of Microglia

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dc.contributor.authorChia Shi Yi
dc.date.accessioned2024-04-12T08:33:47Z
dc.date.available2024-04-12T08:33:47Z
dc.date.issued2023-03
dc.description.abstractIn the present study, a series of aurones incorporating basic amines and lipophilic functionalities at ring A and/or ring B were synthesized to improve upon present sulfuretin activity towards targeting brain microglia while overcoming the blood-brain barrier. The effects of the synthesized aurones on LPS-stimulated BV-2 microglial cells were examined and their modulation to an activated M1 phenotype and alternatively activated M2 phenotype were characterized. Also, the BBB permeability of the aurones were determined using the parallel artificial membrane permeability assay for blood-brain barrier (PAMPA-BBB) model. The results revealed that several aurones showing significant inhibitory activities against nitric oxide (NO) levels of more than 50% at 1 to 10 μM (p < 0.01 versus control).
dc.identifier.urihttps://erepo.usm.my/handle/123456789/18892
dc.subjectSynthesis Of Blood-Brain Barrier Permeable Aurones
dc.subjectModulators Of Microglia
dc.titleSynthesis Of Blood-Brain Barrier Permeable Aurones As Modulators Of Microglia
dc.typeResource Types::text::thesis::master thesis
dspace.entity.typePublication
oairecerif.author.affiliationUniversiti Sains Malaysia
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