Publication: Evaluation of genscript cpass and immusafe covid+ assays in detection of sars-cov-2 neutralising antibody titres in coronavac second and BNT162b2 booster doses
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Date
2023-08
Authors
Izani, Wani Husna Mohd
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Abstract
Coronavirus disease 2019 (COVID-19) outbreak in 2020 was caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). The pandemic has affected a lot
of people worldwide, resulting in COVID-19 vaccines being developed as an effort to
stop the pandemic. The vaccines approved by the Malaysian government include
Sinovac CoronaVac and Pfizer-BioNTech BNT162b2. Vaccination can increase the
level of neutralising antibodies and protect against COVID-19 infections. Neutralising
antibodies are essential in monitoring the effectiveness of the vaccines against SARSCoV-
2. Several assays have been developed to detect neutralising antibody titres in
individuals. The purpose of this study was to evaluate the two commercialized assays,
GenScript cPass and ImmuSAFE COVID+ tests in detecting SARS-CoV-2
neutralising antibody titres. Both assays used a total of 26 serum samples of
CoronaVac second (n = 13) and BNT162b2 booster (n = 13) doses. The study also
determined neutralising antibody titres between males and females among young
adults in second and booster doses. The results showed the titre of neutralising
antibodies was higher in BNT162b2 booster dose than in CoronaVac second dose
serum samples. The analysis of the demographic data showed neutralising antibody
titres in females were higher than in males among young adults in second and booster
dose samples. The study concluded that both assays were reliable in detecting
neutralising antibodies in serum samples following vaccination.