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The usage of sugammadex in Hospital Universiti Sains Malaysia

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dc.contributor.authorAbdillah, Dayang Shariza Abang
dc.date.accessioned2026-10-25T07:26:07Z
dc.date.available2026-10-25T07:26:07Z
dc.date.issued2021
dc.description.abstractBackground: Sugammadex is a selective reversal agent for neuromuscular agent such as rocuronium. It has significant advantages and safety profile compared to the traditionally used neostigmine. However, the use remains restricted due to its high cost. This study was designed to identify whether the indication of sugammadex usage adhered to Malaysian Society of Anaesthesiologists (MSA) protocol, the percentage of neuromuscular monitoring usage and intensive care unit (ICU) admission in patients given sugammadex. Methods: A five-year retrospective cross-sectional study from 2015 to 2019 was conducted in Hospital Universiti Sains Malaysia (HUSM) as an audit on the usage of sugammadex in HUSM. A total of 266 patients were included in this study. Results: Out of 266 patients, 254 patients (95.5%) adhered to MSA protocol’s indication, and 12 patients (4.5%) did not adhere to MSA protocol. Only 18 patients’ reversal (6.8%) was guided by intraoperative neuromuscular monitoring namely the train-of-four (TOF) count and the remaining 248 patients (93.2%) reversal was not guided by neuromuscular monitoring. 241 patients (90.6%) did not require ICU admission and 25 patients (9.4%) required ICU admission of which 19 (7.1%) were anticipated and 6 (2.3%) were unanticipated. Conclusion: Over the years, there was an increasing number of sugammadex usage in HUSM and majority of the patients selected adhered to MSA protocol. This study also revealed that the use of neuromuscular monitoring is still poorly practised although it is strongly recommended in MSA protocol. As this is the first audit on sugammadex in HUSM, future research is still needed to determine its benefits, safety profile and the cost-analysis when compared to neostigmine.
dc.identifier.urihttps://erepo.usm.my/handle/123456789/25221
dc.language.isoen
dc.subjectsugammadex
dc.subjectrocuronium
dc.titleThe usage of sugammadex in Hospital Universiti Sains Malaysia
dc.typeResource Types::text::thesis::master thesis
dspace.entity.typePublication
oairecerif.author.affiliationUniversiti Sains Malaysia
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