Publication: Effect of autologous platelet rich plasma on non-surgical periodontal therapy for periodontitis in selected pakistani patients with uncontrolled type-ii diabetes mellitus
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Date
2023-12
Authors
Athar, Yousaf
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Abstract
The susceptibility to periodontal disease is often cited as the “sixth
complication of diabetes mellitus” making it the most common oral complication of
diabetes. Treatment for periodontal disease includes various non-surgical and surgical
approaches. The metabolic disturbances in diabetic patients may lower their resistance
to infections and may help in both initiation and progression of developing
inflammatory periodontal disease. The use of autologous platelet concentrates has
exhibited considerable promise as a conservative therapy towards periodontal
treatment. The objective of the study was to evaluate the effects of platelet rich plasma
placement in deep periodontal pockets, following non-surgical periodontal therapy
(NSPT) in patients with standardized uncontrolled type II diabetes. The study groups
comprised two patient groups receiving non-surgical periodontal therapy and platelet
rich plasma in two different concentrations and a control group receiving NSPT only.
An inter and Intra group comparison of Periodontal parameters including periodontal
pocket depth, alveolar bone loss and gingival index along with pro-inflammatory
cytokine, Tumour Necrosis Factor Alpha (TNF-α), interleukin 1β (IL-1 β) levels and
C-reactive protein levels was conducted at 45- and 90-day interval. Overall average
age was 50.17 with SD = 7.13. Both interventional groups exhibited statistically
significant gain in bone height. PRP 1 group showed maximum gain in alveolar bone
levels. A trend towards lower HbA1c levels was shown after NSPT and adjunctive PRP placement. The PRP groups exhibited lower the levels of circulating C- reactive
protein. This reduction in levels of pro-inflammatory cytokines in plasma and
improved periodontal parameters indicated a conducive environment towards
periodontal tissue healing and improved diabetic control.