Publication: Production Of Postbiotic By Lactic Acid Bacteria Through Fermentation Process As Potential Antidiabetic Agent
| dc.contributor.author | Shunmugham, Thavan Raj | |
| dc.date.accessioned | 2026-05-07T03:48:29Z | |
| dc.date.available | 2026-05-07T03:48:29Z | |
| dc.date.issued | 2025-03 | |
| dc.description.abstract | In response to the notable adverse health effects associated with the use of chemically synthesized antidiabetic drugs for individuals with diabetes, a comprehensive investigation was undertaken to explore the potential of postbiotic compounds produced by lactic acid bacteria (lab) as novel antidiabetic agents, with a particular focus on their inhibitory effects compared to acarbose. Seven lab strains were cultured to obtain supernatants and heat-killed cell (hkc) which was exposed to 80℃, which were subsequently evaluated for their inhibitory activities against α-amylase and α-glucosidase enzymes. The supernatant from lactobacillus acidophilus tp7 culture exhibited the most significant α-amylase inhibitory activity, with a percentage of 79.01 ± 1.35%, while hkc of lactococcus lactis c22 displayed an inhibition percentage of 58.17 ± 3.08%. For α-glucosidase inhibition, limosilactobacillus reuteri bm5 showed the highest inhibition percentage in both the supernatant and hkc, with percentages of 68.08 ± 0.03% and 67.78 ± 1.18%, respectively. Further fractionation of exopolysaccharide (eps), small molecules, and proteins was carried out, revealing that the crude eps extracted from l. Acidophilus’s supernatant exhibited the most remarkable inhibitory effects, with 95.90% inhibition in the α-amylase test and 75.51% inhibition in the α-glucosidase test, surpassing the other fractionated components | |
| dc.identifier.uri | https://erepo.usm.my/handle/123456789/24121 | |
| dc.language.iso | en | |
| dc.subject | Lactic acid bacteria | |
| dc.title | Production Of Postbiotic By Lactic Acid Bacteria Through Fermentation Process As Potential Antidiabetic Agent | |
| dc.type | Resource Types::text::thesis::master thesis | |
| dspace.entity.type | Publication | |
| oairecerif.author.affiliation | Universiti Sains Malaysia |