Pusat Pengajian Teknologi Industri - Tesis

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The Cdc42 Cys81Tyr Mutation: Impact On Guanosine Triphosphatase (Gtpase) Activation Status And Its Cellular Functions
(2025-08)
Chong, Chien Fung
Mutations in small Rho guanine triphosphatase (GTPase) have been increasingly associated with various diseases. One of the members is Cdc42, a key regulator of cellular signalling, cytoskeletal organization, and immune responses by cycling between an active GTP-bound and an inactive GDP-bound states. A novel cysteine-to-tyrosine substitution at residue 81 (C81Y) within the β4 segment of Cdc42 has been identified in patients with concurrent primary immunodeficiency (PID) and Hodgkin's lymphoma. Notably, emerging evidence suggests that this mutation disrupts Cdc42 structure-function relationship, potentially impairing immune signalling, altering cytokine secretion profiles, and driving oncogenesis. Yet, the pathogenic roles of Cdc42 C81Y remains poorly understood. This study investigates its structural and biochemical impact, hypothesizing that it disrupts GDP/GTP cycling, post-translational modification, and downstream signalling, contributing to disease pathogenesis.
Potensi Bacillus Subtilis Dalam Mengurangkan Kepekatan Ammonia Di Ruang Tertutup Melalui Semburan Bioorganik
(2025-01)
Saidun, Syahanim
Kajian ini bertujuan untuk menghasilkan semburan bio mesra alam yang tidak membahayakan pengguna dan kepelbagaian mikrob dalam tangki sanitari, bagi mengatasi masalah bahan kimia berbahaya dalam penyegar udara. Kajian dibahagikan kepada tiga fasa utama. Fasa 1 melibatkan penghasilan b.Subtilis kering. Fasa 2 menggunakan dua kaedah, yang pertama, penjerapan b.Subtilis ke dalam arang dengan pengocakan berbeza, dan kedua, memasukkan b.Subtilis ke dalam air suling pada kepekatan yang berbeza. Kedua-dua kaedah diuji dalam kotak kebuk udara untuk melihat penurunan bacaan ammonia. Keputusan menunjukkan kaedah penjerapan b.Subtilis dalam arang tidak memberikan kesan yang baik, manakala kaedah kedua berjaya mengurangkan kadar ammonia sebanyak 0.5 g/l. Kaedah semburan ini kemudian digunakan dalam empat zon yang berbeza dan ianya juga menunjukkan pengurangan faktor lain seperti pm2.5, pm 10, pm 1.0, hcho dan tvoc. Fasa 3 mendapati keadaan optimum berlaku pada suhu 37°c, ph 7, pengocakan 150 rpm, kepekatan b.Subtilis 1.0 g/l dan dos ammonia 4 ml/l. Walaupun b.Subtilis kerap digunakan untuk mengurangkan kadar ammonia, kajian ini menekankan kepentingan mengkaji kaedah penggunaan yang tepat termasuk kepekatan dan kaedah penyediaan.
Surface Modification Of Corn Starch-Based Nanomaterials For The Encapsulation Of Vitamin D3 And Magnesium, And As Lead And 2,4dichlorophenol Adsorbents
(2025-08)
Badran, Amal Mohammad Ahmad
Researchers have explored ways to deliver micronutrients like magnesium and vitamin D3, but issues such as slow hydration and poor water compatibility have limited progress. At the same time, pollutants like lead and 2,4-DCPh pose serious health risks, and conventional removal methods are often costly or unsustainable. Thus, there is a need for safe, eco-friendly, and cost-effective adsorbents to protect public health. This study aims to fabricate starch nanomaterials (SNM) as an effective nanocarrier for VD3 and Mg+2, and as a nano-detoxicant for Pb and 2,4DCPh.
All Cellulose Composites Productions From Oil Palm Empty Fruit Bunches
(2025-01)
Jaafar, Mohd Zaim
This research study the formulation and properties of all cellulose composite (acc) films isolated from oil palm empty fruit bunch (opefb) using 8% lithium chloride/n-n dimethylacetamide (licl/dmac) solvent and a surface-selective dissolution technique. Opefb is an abundant yet underutilized renewable resource in malaysia. In response to the growing demand for sustainable, high-performance materials, this study investigates into the impact of process condition parameters on the tensile, structural, thermal, and water interaction characteristics of acc films. The fabrication of acc involved utilizing process condition parameters formulations with dissolution times of 5, 15, 30, and 45 minutes, combined with initial cellulose concentrations of 1%, 3%, and 5%. A straightforward pulping, bleaching, and solution casting technique were employed to extract opefb cellulose pulp, ensuring efficient film fabrication. Tensile analysis reveals that the best combination of 3% initial cellulose concentration and 15 minutes dissolution time results in acc films with superlative tensile strength (44.41 mpa) and young’s modulus (3.26 gpa). X-ray diffraction (xrd) studies reveal a structural transition of the dissolved cellulose from cellulose i to cellulose ii, while also confirming the coexistence of both cellulose i and ii phases., leading to a notable decrease in the degree of crystallinity observed in acc films.
Enrichment Of Flavonoids From Kenaf (Hibiscus cannabinus L.) Using Macroporous Adsorption Resins And Evaluation Of Their Diabetic Wound Healing Properties On Adult Zebrafish Model
(2025-09)
Ali, Aljawarneh Raghad Yousef
Diabetes mellitus is a chronic disease affecting millions worldwide, with approximately 340 million diagnosed cases. A significant complication is impaired wound healing, affecting nearly 25% of diabetic patients. Conventional treatments, including medications, dressings, and surgeries, are costly and may cause side effects. As a result, natural alternatives such as flavonoids are gaining interest for their antioxidant, anti-inflammatory, and antimicrobial properties. Kenaf, a plant rich in flavonoids, has potential therapeutic benefits for diabetic wound healing. This study aimed to extract and enrich flavonoids from kenaf and evaluate their antioxidant, anti-inflammatory and wound healing properties using both non-diabetic and diabetic adult zebrafish (Danio rerio) models.

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