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Computational Elucidation Of Binding Interactions For Thicapa And Poet On Amyloid Beta 42 And Presenilin 1 In Treating Alzheimer’s Disease

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dc.contributor.authorMohd Suhaimi, Ahmad Marwazi
dc.date.accessioned2025-10-13T08:01:47Z
dc.date.available2025-10-13T08:01:47Z
dc.date.issued2024-01
dc.description.abstractAD begins with memory and cognitive impairment and progresses to speech and movement skills which affects 35% of 80-year-olds adult. According to the amyloid cascade hypothesis, two proteins which are Amyloid Precursor Protein (APP), and Presenilin 1 (PS1) play a vital role in contributing to AD. Mutated APP and PS1 are shown to be responsible for the production of pathogenic amyloid-beta (Aβ42) peptide in AD patient, which then forms Aβ42 plaques and deposited in the brain. Presenilin 1 (PS1) is the primary component of γ-secretase which catalyses the cleavage of APP (neuron development) especially at the beta region of APP in both amyloid pathways.
dc.identifier.urihttps://erepo.usm.my/handle/123456789/22762
dc.language.isoen
dc.subjectAlzheimer's disease
dc.subjectAmyloid beta-protein
dc.titleComputational Elucidation Of Binding Interactions For Thicapa And Poet On Amyloid Beta 42 And Presenilin 1 In Treating Alzheimer’s Disease
dc.typeResource Types::text::thesis::master thesis
dspace.entity.typePublication
oairecerif.author.affiliationUniversiti Sains Malaysia
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