Publication: Pembangunan Pelantar Penghantaran Laluan Isyarat Berasaskan Sel Stem Mesenkima Untuk Terapi Bersasar Tumor Her2-Positif
No Thumbnail Available
Date
2024-11
Authors
Sun, Yuliang
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Her2 (+) tumours have the characteristics of strong migration, poor sensitivity to chemotherapy drugs, poor recovery, easy recurrence, and high malignancy. However, traditional methods of targeted treatment are often hindered by biological barriers, which isolate drug molecules in healthy tissues and cause damage to normal cells. Here, the study designed an intelligent delivery platform by introducing artificial signal pathways to mesenchymal stem cells (msc). This intelligent delivery platform is different from traditional targeting of tumour microenvironment or enhancing affinity with tumours, endowing the delivery platform with tumour signal recognition ability, enabling it to autonomously distinguish between tumours and normal tissue cells, and feedback editing instructions. Specifically, the artificial signalling pathway of msc is divided into two parts: recognition structure and response structure, which respectively play a role in identifying tumours and responding to tumour signals. To enable msc to efficiently release drugs, this study endowed msc with affibody-notch (core)-vp64-gal4/uas-hsv-tk artificial signalling pathway and constructed an intelligent delivery platform for controllable drug release (mscintelligent).