Publication: Screening of the anti-proliferative effects of baicalein and carbon nanodot combination on hela cancer cells
| dc.contributor.author | Partheeban, Yugaashini | |
| dc.date.accessioned | 2025-12-21T00:41:42Z | |
| dc.date.available | 2025-12-21T00:41:42Z | |
| dc.date.issued | 2025-01 | |
| dc.description.abstract | This study identifies the anti-proliferative effects of a novel combination therapy using baicalein, a flavonoid, and carbon nanodots (CDs) on HeLa cervical cancer cells. Baicalein, known for its potent anti-cancer properties, has shown limitations in clinical applications due to low bioavailability. Carbon nanodots, with their excellent biocompatibility, solubility, and drug delivery potential, were used as a carrier to enhance the therapeutic efficacy of baicalein. The study evaluated the anti-proliferative effects of the baicalein-carbon nanodot (Bai-CDs) combination in comparison to standalone treatments of baicalein, CDs, and cisplatin on HeLa cells using the MTT assay. Results demonstrated that the combination therapy significantly inhibited cell proliferation in a dose-dependent manner with the IC50 69.85 ± 4.145μg/ml and p-value less than 0.05. These findings highlight the potential of the Bai-CDs combination as a new therapeutic strategy for cervical cancer, providing enhanced bioavailability and targeted anti-cancer effects while minimizing adverse outcomes associated with conventional chemotherapy | |
| dc.identifier.uri | https://erepo.usm.my/handle/123456789/23354 | |
| dc.language.iso | en | |
| dc.subject | - | |
| dc.title | Screening of the anti-proliferative effects of baicalein and carbon nanodot combination on hela cancer cells | |
| dc.type | Resource Types::text::thesis::bachelor thesis | |
| dspace.entity.type | Publication | |
| oairecerif.author.affiliation | Universiti Sains Malaysia |