Publication: In Vitro Anti Cancer Properties Of Thiadiazole Coumarin Derivatives Against Colon Cancer
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Date
2019-05
Authors
Furqan Faisal, Sarah
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Abstract
Thiadiazole coumarin derivatives have been shown to be promising anti-cancer
agents. In this study, five different thiadoazole coumarin derivatives (TCDs) were
studied for their anticancer activity towards colorectal, breast and lung carcinoma. The
TCDs {(OCH3-TC 1), (H3CO-TC 2), (H3CO-TC 3), (Br-TC 4), & (OH-TC)} are
different in their structures. The compounds were tested for two important pathways of
carcinogenesis namely angiogenesis and apoptosis. Angiogenesis is a process of new
blood vessel development which is crucial for neoplastic tissues to obtain nourishment
for their growth and metastasis.
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Keywords
Anti Cancer , Colon Cancer