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Study On The Effects Of Catharanthus Roseus-silver Nanoparticles On Human Hepatocellular Carcinoma Cell Line Hepg2

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dc.contributor.authorAzhar, Nur Asna
dc.date.accessioned2025-06-12T08:52:30Z
dc.date.available2025-06-12T08:52:30Z
dc.date.issued2024-09
dc.description.abstractCancer is a major global health challenge that continues to increase worldwide, posing a significant obstacle to achieving long life expectancy. Conventional chemotherapy drugs may not be specific enough, leading to significant side effects and harm to healthy cells. Therefore, alternative cancer therapies are crucial, and application of silver nanoparticles (AgNPs) presents a novel approach to cancer treatment due to their unique features. Utilising plants for the biosynthesis of AgNPs offers several advantages over other methods. Numerous studies had reported that plant mediated AgNPs synthesis have been found to exhibit potent anticancer activity against various cancer cell lines. Thus, the antiproliferative effects and selective index (SI) of Catharanthus roseus-silver nanoparticles (C. roseus-AgNPs) on hepatocellular carcinoma (HepG2) cells were determined by using normal liver cell line (THLE-3) as a control. C. roseus-AgNPs was more potent than C. roseus-aqueous extract in inhibiting the proliferation of HepG2 cells while exhibiting less inhibition towards THLE-3 cells. C. roseus-AgNPs demonstrated selective toxicity towards HepG2 cells with a high SI value (>2) compared to camptothecin. For both C. roseus-AgNPs and C. roseus-aqueous extract treatments, several apoptotic features were detected when observed using IncuCyte live-cell analysis system, including cell shrinkage, rounded cells, and retracted. The underlying mechanisms associated with the inhibitory effects in the treated cells were further explored.
dc.identifier.urihttps://erepo.usm.my/handle/123456789/22147
dc.language.isoen_US
dc.subjectStudy On The Effects Of Catharanthus Roseus-silver Nanoparticles
dc.subjectCatharanthus Roseus-silver Nanoparticles
dc.subjectHuman Hepatocellular Carcinoma
dc.subjectCell Line Hepg2
dc.subjectSeptember 2024
dc.subjectAzhar
dc.subjectNur Asna
dc.subjectInstitut Perubatan dan Pergigian Termaju
dc.titleStudy On The Effects Of Catharanthus Roseus-silver Nanoparticles On Human Hepatocellular Carcinoma Cell Line Hepg2
dc.typeResource Types::text::thesis::doctoral thesis
dspace.entity.typePublication
oairecerif.author.affiliationUniversiti Sains Malaysia
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