Institut Perubatan & Pergigian Termaju - Tesis
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- PublicationDevelopment Of Multi-Loci Sequence-Based Genetic Diagnostic Testing Strategy For Severe Combined Immunodeficiency (Scid) Patients In Malaysia(2024-02)Habib Dzulkarnain, Syarifah MasyitahThe central objective of this thesis was to establish a qPCR-based assay of SCID gene panel based on patients investigated for SCID that involving 9 genes: RAG1, RAG2, DCLRE1C, LIG4, ADA, IL2RG, JAK3, IL7Rα and PNP by using qPCR-based assay.
- PublicationThe Role Of Rarβ Gene On Cancer Stemness Capability In Non-Small Cell Lung Cancer Cell Line(2024-03)Abu Halim, Noor HanisThis study was conducted to understand the role of RARβ in CSCs maintenance by using lentivirusmediated shRNA for RARβ to knock down RARβ mRNA levels in A549 putative CSCs (A549 CD166+CD44+ and A549 CD166+EpCAM+) and A549 putative non- CSCs (A549 CD166-CD44- and A549 CD166-EpCAM-).
- PublicationHuman Wharton’s Jelly-Derived Mesenchymal Stem Cells Promote Corneal Epithelial Growth On Polyhydroxyalkanoate For Corneal Regeneration(2022-12)Mohamed, Mohamed Salih ElnourCorneal transplantation has limitations such as graft rejection, disease transmission, and scarcity of tissue supply. Tissue engineering and regenerative medicine technology for future corneal diseases treatment strategies involve the use of safe, commonly available, biocompatible, and biodegradable polymer, together with the biologically active molecules and stem cells. Polyhydroxyalkanoate (PHA) was biosynthesized and characterized by testing the monomer composition and water contact angle. In vitro degradation was explored using lipase enzyme.
- PublicationThe Evaluation Of Endoplasmic Reticulum Stress Among Regular Kratom Users And Its Implications For Kratom Dependence And Kratom Induced Depressive Symptoms(2024-03)Yang, BinRecent research showed that psychoactive substances can induce endoplasmic reticulum (ER) stress and unfolded protein response (UPR). This case-control study filled the research gap by: (1) determining the association between kratom use characteristics (such as the age of first kratom use, the duration of kratom use, the average frequency and quantity of daily kratom use, and the time since last kratom consumption prior to blood collection for analysis) and the mRNA and protein expression of ER stress sensors; and (2) assessing the correlations between the mRNA and protein expression of ER stress sensors and severity of kratom dependence and kratom induced depressive symptoms during kratom abstinence.
- PublicationIdentification, Growth Study, Encapsulation And Characterization Of Potential Prebiotic And Probiotic Extracted From Selected Fruit Peels(2024-03)Akter, BeautyThis study focused on waste utilization for an economical and alternative natural source of potential prebiotic and probiotic production. Moreover, prebiotic-based biopolymeric encapsulation was also conducted to develop synbiotic powder for improved survival of Lactobacillus plantarum CAM 4 under gastrointestinal and storage conditions. Phase 1 of the study aimed to assess the prebiotic potential of watermelon rind/peel, pineapple, and banana peels by analysing their impact on the growth rate of probiotics.