Institut Perubatan & Pergigian Termaju - Tesis

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    Physico-Mechanical And Biological Evaluation Of Three-Dimensional Printed Thermoplastic Polyurethane And Polylactic Acid Scaffold For Tracheal Tissue Engineering
    (2023-02)
    Samat, Asmak Abdul
    Surgical restoration of extensive tracheal lesions is complicated, and it necessitates the use of a biocompatible, mechanically stable, and non-toxic material that degrades gradually to overcome the limitation of allografts. A three-dimensional (3D) printed tracheal scaffold produced from polymers is one option for addressing some of the challenges in tracheal transplantation. Polymer blending is one approach for creating material with specific properties for a trachea scaffold. The goal of this study was to evaluate the physical, mechanical, and biological properties of thermoplastic polyurethane (TPU) and polylactic acid (PLA) blend as prospective tracheal replacement materials. Both materials are well-known for their promising properties when utilised independently, thus broadly employed in various applications, especially in the biomedical field. It is hypothesised that combining the two materials and the subsequent 3D printing method produces a composite with suitable qualities for tracheal replacement. Different TPU and PLA compositions were melt-blended and characterised for their physical and mechanical properties,
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    Class Iii Skeletal Base In Malay Population: Characterisation Of Skeletal Phenotypes And Association With Familial Inheritance
    (2023-03)
    Ran, Arron Lim Yan
    Class III skeletal discrepancy results from the disproportionate growth of the maxilla and mandible. Dentofacial skeletal features vary significantly between different ethnicities and Class III malocclusions, which are difficult to treat, were highly prevalent in Malaysians compared to other races. In the Malay population, the skeletal phenotypes of Class III skeletal base have never been investigated. Therefore, the general objective of this study was to investigate and characterise the different Class III skeletal phenotypes in a racially homogenous adult Malay population and determine their association with familial inheritance. This study also sought to determine the prevalence of Class I, Class II and Class III skeletal base among Malay patients attending the Advanced Medical and Dental Institute (AMDI) orthodontic clinic, determine the precursor for genetic analysis using multivariate reduction method and ascertain the proportion of familial occurrence of Class III skeletal base.
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    Analysis Of Phytochemical Compounds, Antioxidant And Anti-Inflammatory Activities Of Methanolic Extract Of Ruthana Date Fruits (Phoenix Dactylifera)
    (2023-03)
    Faris, Alsarayrah Nosiba Atallah
    Ruthana date fruit, one of the finest types of dates, contains various nutrients and phytochemical compounds important for human health. Therefore, it is important to highlight the analysis of the medicinal value of these fruits in studies related to clinical nutrition. In this study, phenols, and flavonoid contents of date fruit methanolic extract (DFME) were measured due to their importance in inhibiting activities of free radicals. The antioxidant activities of the extract were evaluated by several analytical methods, which include 2,2-Diphenyl-1-Picrylhydrazyl radical scavenging assay (DPPH), Ferric reducing antioxidant power (FRAP), 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging assay (ABTS+), and nitric oxide radical scavenging assay (NO). In addition, the anti-inflammatory effects of DFME were studied in vitro using albumin denaturation, and red blood cell membrane stabilization assays. The results showed that DFME contains a high value of polyphenol compounds.
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    Molecular Toxico-Pathology Responses Of EUDRILUS EUGENIAE TO 2- AMINO-l-METHYL-6-PHENYLIMIDAZO[4,5- bJPYRIDINE (PhIP) AND 2-AMINO-3,8- DIMETHYLIMIDAZO [4,5-f]QUINOXALINE (MeIQx)
    (2019-01)
    Balogun, Wasiu Gbolahan
    The carcinogenic risks of highly heated proteinaceous foods are at large associated with the formation of heterocyclic amines (HCAs), evidence in their substantial presence in the biota. The earthworm Eiidrilus eugeniae (E. eugeniae) is a terrestrial ubiquitous animal, susceptible to toxicity from environmental contamination, and a suitable model for understanding the mechanism of toxic agents such as HCAs. Thus, this study elucidated the vulnerability of E. eugeniae to HCAs induced toxicity using a modified OECD TG207 approach.
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    Effects Of Human Umbilical Cord-Derived Mesenchymal Stem Cells On Human Corneal Epithelial Cells’ Growth
    (2019-12)
    Ex vivo cultivated corneal limbal stem cell (LSC) transplantation is the contemporary therapy for comeal epithelial regeneration. The success rate of this therapy is dependent on the cell culture conditions and the carrier system. Human umbilical cord mesenchymal stem cells (hUC-MSCs) has regenerative ability and are rich with paracrine factors. Cells cultivated in spherical scaffolds could provide a similar in vivo environment to the cell niche and may positively alter the stem cells properties. This study aims to improve the cellular quality of the comeal epithelial transplantation graft using a robust cell population method. Human telomere modified comeal epithelial cells (hTCECs) were co-cultured in direct and indirect cell culture with hUC-MSCs. Characterisation of corneal markers p63, ABCG2, ABCB5, and differentiation marker K3 were performed.