Publication: he effects of scorodocarpus borneensis against drug-induced nephrotoxicity
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Date
2025-02
Authors
Raymond, Mohammad Aiman
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Abstract
Diabetes mellitus is a chronic metabolic disorder characterised by insufficient insulin production or impaired insulin utilisation, leading to persistent hyperglycaemia. If left unmanaged, it can result in severe complications, including diabetic nephropathy, a progressive kidney disorder commonly associated with long-term diabetes. While metformin is a standard treatment for controlling blood glucose levels, its side effects, such as diarrhoea, vomiting, and lactic acidosis, have raised concerns, emphasizing the need for safer alternatives. Therefore, the aim of the study the effects of Kulim fruit aqueous extracts against diabetic nephropathy-induced Sprague-Dawley rats. The effect of Kulim fruit extract was studied on Vero cells and the diabetic nephropathy- induced Sprague -Dawley rats. The proliferation assay result of Kulim fruit extract obtained shown not significant percentage of cell viability when compared to metformin (p>0.05), might be due to lab technical settings. In this study, the induction of the type 2 diabetes was carried out using high-fat diet (HFD) for 4 weeks followed by injection of 55mg/kg of STZ for one week. The animals were divided into 4 groups with sample size of n=3, which were normal control, diabetic control, metformin-treated (150mg/kg) and Kulim fruit extract- treated (1000mg/kg) group. The effects of the Kulim fruit extract on serum creatine level shown significant different between treated and untreated group (p<0.05). The effects of Kulim fruit extract on blood urea nitrogen (BUN) shown significant different between treated and untreated group (p<0.05). The histopathological study shows promising effects in treating diabetic nephropathy when compared to untreated diabetic nephropathy by assessing the morphology of the glomerulus, Bowman’s space and tubules in kidney organ. The findings may provide valuable insights into Kulim fruit extract as a natural therapeutic alternative for diabetic nephropathy, offering a safer complementary approach to conventional treatments. Hence, the long term-impact of Kulim fruit extract in diabetic nephropathy model must be studied over a longer period
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