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Design, Synthesis, In Silico And In Vitro Evaluations Of New Inhibitors Targeting Human Hypoxia Inducible Factor (Hif) Prolyl Hydroxylase Domain (Phd) Enzymes

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dc.contributor.authorMohammad, Sayaf Abrar
dc.date.accessioned2026-08-19T06:56:52Z
dc.date.available2026-08-19T06:56:52Z
dc.date.issued2025-09
dc.description.abstractHypoxia inducible factor (HIF) prolyl hydroxylase domain (PHD) enzymes play a pivotal role in oxygen sensing and regulation, making them key therapeutic targets for hypoxia-related diseases, including cardiovascular diseases (CVDs), chronic kidney disease (CKD), and anemia. However, current PHD inhibitors suffer from significant limitations, including toxicity, thromboembolic risks, and poor selectivity, necessitating the discovery of safer and more effective alternatives. This research utilises a computational-experimental methodology to discover new PHD inhibitors through the integration of molecular docking, molecular dynamics (MD) simulations, and free energy calculations, QSAR modeling, and experimental validation.
dc.identifier.urihttps://erepo.usm.my/handle/123456789/24864
dc.language.isoen
dc.subjectDesign
dc.subjectSynthesis
dc.subjectIn Silico And In Vitro Evaluations
dc.subjectNew Inhibitors Targeting Human Hypoxia Inducible Factor (Hif) Prolyl Hydroxylase Domain (Phd) Enzymes
dc.titleDesign, Synthesis, In Silico And In Vitro Evaluations Of New Inhibitors Targeting Human Hypoxia Inducible Factor (Hif) Prolyl Hydroxylase Domain (Phd) Enzymes
dc.typeResource Types::text::thesis::doctoral thesis
dspace.entity.typePublication
oairecerif.author.affiliationUniversiti Sains Malaysia
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