Publication: T Cell And Macrophage Interaction In Experimental Bleomycin-Induced Idiopathic Pulmonary Fibrosis
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Date
2025-02
Authors
Gu, Yanrong
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Abstract
Pulmonary fibrosis is a progressive and irreversible disease with poorly understood aetiology and high mortality rates. The cell interactions in immune regulation play a pivotal role in disease progression. While macrophages have been extensively studied in lung fibrosis models, their interactions with other cells, especially with T cells remain largely unknown. Particularly, the crosstalk between innate immunity and adaptive immunity is of great interest. The current study was performed to determine the effect of macrophages and T cells interaction on pulmonary fibrosis progression. Firstly, the increase and activation of T cells were validated in a mouse model of bleomycin (BLM)-induced pulmonary fibrosis. Then, the impact of T cells on disease progression was investigated using CD3e knockout (CD3e KO) T cell-deficient mice. Surprisingly, the absence of T cells resulted in markedly more severe lung fibrosis, accompanied by a significant increase in interstitial macrophages (IMs).
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Idiopathic Pulmonary Fibrosis