Publication: The evaluation of etlingera elatior flower (bunga kantan) aqueous extract (EEAE) on fatty liver disease in hypercholesterolaemic rats
| dc.contributor.author | Ting, Betty Wong Shi | |
| dc.date.accessioned | 2025-11-25T01:29:49Z | |
| dc.date.available | 2025-11-25T01:29:49Z | |
| dc.date.issued | 2025-01 | |
| dc.description.abstract | Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease with increasing prevalence worldwide. Hypercholesterolaemia (HC) is the leading cause of NAFLD because excessive high-cholesterol diet (HCD) intake disrupts cholesterol homeostasis. The current medications for NAFLD treatment bring various side effects, and there are no drugs approved by the Food and Drug Administration (FDA). A medicinal plant, Etlingera elatior flower, exhibits antioxidants and hepatoprotective properties. This study aims to evaluate the effects of Etlingera elatior flower (bunga kantan) aqueous extract (EEAE) on the HCD-induced hypercholesterolaemic rat model. Eighteen male Sprague-Dawley (SD) rats were randomly divided into three groups (n = 6): control rat (Group 1), HC-untreated rat (Group 2), and HC-treated 1000 mg/kg EEAE rat (Group 3). The rats were fed HCD for six weeks to induce HC, followed by six weeks of oral EEAE treatment. EEAE significantly reduced body mass index (BMI) and blood cholesterol levels. The histopathological examination of livers for Haematoxylin and Eosin (H&E) staining and Masson’s Trichrome (MT) staining was evaluated. The HC-untreated group developed non-alcoholic steatohepatitis (NASH), characterised by macrovesicular steatosis, inflammation, ballooning degeneration, and fibrosis. In contrast, the liver tissue in the HC-treated EEAE group was reversible from NASH to non-alcoholic fatty liver (NAFL). Furthermore, E. elatior flower was evaluated for its nutritional composition, and HPLC analysis demonstrated that EEAE contains high levels of cyanidin-3-O-glucoside chloride. The effect of EEAE on the liver weight to body weight ratio required further evaluation. Liver function tests (LFT) and lipid profile tests were conducted to evaluate the effect of EEAE in hypercholesterolaemic rats. Overall, EEAE exhibits antioxidant, anti-inflammatory, and antihypercholesterolaemia effects in the liver | |
| dc.identifier.uri | https://erepo.usm.my/handle/123456789/23137 | |
| dc.language.iso | en | |
| dc.subject | - | |
| dc.title | The evaluation of etlingera elatior flower (bunga kantan) aqueous extract (EEAE) on fatty liver disease in hypercholesterolaemic rats | |
| dc.type | Resource Types::text::thesis::bachelor thesis | |
| dspace.entity.type | Publication | |
| oairecerif.author.affiliation | Universiti Sains Malaysia |