Publication: Correlation of serum prolactin and thyroid stimulating hormone concentration among infertile women: A systematic review and meta-analysis
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Date
2022
Authors
Ramadras, Delini Devi
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Abstract
Background: Infertility affects millions of people of reproductive age worldwide. Thyroid hormones and prolactin (PRL) affect reproduction and pregnancy; therefore, these two hormones influence fertility. This systematic review and meta-analysis aimed to summarise the strength of the correlation between serum PRL and thyroid stimulating hormone (TSH) among infertile women and to explore selected factors influencing the correlation. Method: Systematic search of online databases (PubMed, Scopus, Science Direct, SAGE and Google Scholar) from inception until March 2021 and manual search of bibliographies of the included studies was conducted to identify relevant studies. The original research paper describing the correlation or association between PRL and TSH among reproductive-age women with infertility (primary and secondary) was included. The risk of bias was assessed using the Joanna Briggs Institute Critical Appraisal Checklist for Analytical Cross-Sectional Studies. A random effect model was used to estimate the pooled correlations of PRL and TSH, followed by an assessment of heterogeneity and sensitivity analysis. Results: From a total of 822 relevant articles identified, eleven articles were eligible and included in this systematic review and meta-analysis. The random effect pooled correlation estimates between PRL and TSH was 0.431 (95% CI: 0.251, 0.582) with substantial heterogeneity between the included studies (I2=80%, 2=0.067, p<0.001). No significant publication bias was observed. Furthermore, study region, types of infertility, sample size and year of the study did not influence the correlation estimates. Conclusion: Our results highlighted a significant positive moderate correlation between serum PRL and serum TSH among infertile women
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Keywords
Thyroid stimulating hormone , prolactin