Publication: Association between types of mammographic breast density and histological subtypes of invasive breast carcinoma
| dc.contributor.author | Ahmad, Nur Haneefa | |
| dc.date.accessioned | 2026-04-08T23:50:34Z | |
| dc.date.available | 2026-04-08T23:50:34Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | Background: Mammographic density is an established risk factor for breast cancer. It reflects the relative component of fat, epithelial tissue, and connective tissues that has a specific appearance due to different tissue attenuation on the mammogram. Women with dense breast have more epithelial and connective tissue and less fat tissue, and are at higher risk to get breast cancer. Histological subclassification of breast cancer can be divided into invasive carcinoma of no special type (NST) and special types (ST) which include lobular, tubular, cribiform, metaplastic, apocrine, mucinous, papillary, and many others. From various works of literature, the majority of ST breast carcinoma carries a better prognosis than NST. Thus, appropriate classification can allow accurate estimation of a patient’s prognostication and facilitate the identification of optimal treatment strategies. The purpose of this study is to evaluate the association between mammographic breast density and histological subtypes of invasive breast carcinoma. Methods: A cross-sectional study was conducted in Hospital Universiti Sains Malaysia (USM), Kota Bharu, Kelantan, Malaysia on 125 patients who had been diagnosed with breast carcinoma and had undergone mammogram prior to surgery. Breast density was determined using the Breast Imaging Reporting and Data System (BI-RADS) and Tabar classification. It was divided into dense (BI-RADS C and D, Tabar type I, IV, and V) and non-dense (BI-RADS A and B, Tabar II, and III) categories. Histological subtypes of breast carcinoma are categorized into invasive carcinoma of no-special type and special type breast carcinoma. The association between mammographic breast density and histological subtypes of breast carcinoma had been carried out using Pearson chi square test. Cohen’s kappa analysis was done to determine the agreement between BI-RADS and Tabar classification. Results: There is no significant association between mammographic breast density using BI-RADS and Tabar classification with histological subtype (p=0.833 and p=0.336 respectively). However, Cohen’s kappa analysis shows good agreement between BI-RADS and Tabar classification, with a Cohen’s kappa coefficient of 0.8 (p < 0.001) Conclusion: Our study shows no significant association between mammographic breast density and histological subtypes of invasive breast carcinoma. However, with limited literature, further research might be plausible to show the association between breast density and histopathological subtypes of breast carcinoma | |
| dc.identifier.uri | https://erepo.usm.my/handle/123456789/23873 | |
| dc.language.iso | en | |
| dc.subject | invasive breast carcinoma | |
| dc.subject | mammographic breast density | |
| dc.title | Association between types of mammographic breast density and histological subtypes of invasive breast carcinoma | |
| dc.type | Resource Types::text::thesis::master thesis | |
| dspace.entity.type | Publication | |
| oairecerif.author.affiliation | Universiti Sains Malaysia |