Publication: Tomographic sensitivity analysis of spect/ct detectors equipped with low energy high resolution collimators at different tc-99m activity levels
| dc.contributor.author | Zulkarnain, Aina Nadhirah | |
| dc.date.accessioned | 2025-10-13T08:16:12Z | |
| dc.date.available | 2025-10-13T08:16:12Z | |
| dc.date.issued | 2025-07 | |
| dc.description.abstract | Single Photon Emission Computed Tomography/Computed Tomography (SPECT/CT) is a key hybrid imaging technique in nuclear medicine, combining functional and anatomical data for improved disease detection and management. While planar sensitivity is well-studied, the tomographic sensitivity of SPECT/CT detectors with low energy high resolution (LEHR) collimators at varying Tc-99m activity levels remains underexplored. This study examines the effects of Tc-99m activities and LEHR collimator characteristics on tomographic sensitivity, spatial resolution, image contrast, and quantification accuracy. A Jaszczak phantom was scanned using a SPECT/CT system with LEHR collimators at Tc-99m activity levels of 7 mCi, 10 mCi, and 12 mCi. Standard acquisition and reconstruction protocols were used. Tomographic sensitivity was measured in counts per second per millicurie (cps/mCi), spatial resolution was assessed via phantom rod visualisation, and image contrast and relative error were calculated from defined regions of interest. Results show increasing Tc-99m activity enhances tomographic sensitivity which was 176.49 cps/mCi at 7 mCi to 209.45 cps/mCi at 12 mCi, spatial resolution (smaller rods visible at 12 mCi), and contrast the larger spheres showed more negative contrast (e.g., −47% for 31.8 mm at 7 mCi), which improved with higher activity. Smaller spheres exhibited greater variability and higher relative errors. In summary, Tc-99m activity and LEHR collimator design significantly influence tomographic sensitivity, spatial resolution, and image contrast in SPECT/CT imaging. Optimising activity levels and system parameters is vital for enhanced image quality and reducing radiation dose, providing critical insights for clinical protocol improvement in nuclear medicine. | |
| dc.identifier.uri | https://erepo.usm.my/handle/123456789/22763 | |
| dc.language.iso | en | |
| dc.subject | - | |
| dc.title | Tomographic sensitivity analysis of spect/ct detectors equipped with low energy high resolution collimators at different tc-99m activity levels | |
| dc.type | Resource Types::text::thesis::bachelor thesis | |
| dspace.entity.type | Publication | |
| oairecerif.author.affiliation | Universiti Sains Malaysia |