Publication: Mechanistic Evaluation Of Menstrual Blood-Derived Endometrial Stem Cells In Mutine Models Of Alsoholic And Non-Alcoholic Fatty Liver Disease
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Date
2025-03
Authors
Jiang, Yan
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Abstract
Fatty liver disease (fld), encompassing alcoholic liver disease (ald) and non-alcoholic fatty liver disease (nafld), is a major chronic liver condition. Ald is among the top 30 causes of death globally, while nafld prevalence has risen to 38%. Both conditions can progress to steatohepatitis, cirrhosis, or ultimately hepatocellular carcinoma (hcc), current available treatment drugs have many side effects. Human endometrial or menstrual blood-derived mesenchymal stem cells (menscs) offer significant advantages over other mesenchymal stem cells (msc) sources due to their non-invasive collection, ethical accessibility, higher yield, and rapid proliferation rates, thus making them a promising therapeutic option. However, the specific applications and mechanisms of menscs in treating ald and nafld are still under investigation. This study aimed to explore the therapeutic effects and molecular mechanisms of menscs on ald and nafld in mice. Menscs were initially administered to mouse models of ald induced by alcohol and nafld induced by a high-fat diet to assess their protective effects. The evaluation utilized a comprehensive array of biochemical markers, histological analyses, rna sequencing, and gene and protein analyses to elucidate the roles menscs in ameliorating ald and nafld.
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Regenerative medicine