Publication: Determination of group B streptococcus (gbs) serotypes, its virulenece genes and patient’s clinical presentation among non-pregnant adults in Kelantan
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Date
2021
Authors
Sulung @ Ab Hadi, Faridah
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Abstract
Background: GBS infection among non-pregnant adults is emerging nowadays. The
severity of the disease caused by GBS depends on the serotype and presence of
virulence genes in the particular strains. This study aimed to determine the distribution
of GBS serotypes and virulence genes and to know the association of GBS serotype
with the clinical disease.
Methods: A cross-sectional study involving retrospective record review was done
involving a total of 75 GBS isolates collected from October 2018 till October 2019 in
two major hospitals in Kelantan (East coast of peninsula Malaysia). Those isolates
were from various clinical samples of non-pregnant adults > 18 years old (excluding
vaginal swab). Identification of all isolates serotype (serotype Ia, Ib, II until IX) and
their virulence genes (scpB, lmb, bca, bac, rib, cylE, and hylE) were done using
conventional PCR. The antibiotic susceptibility testing was traced from The BIOMIC
V3, Microbiology System. Clinical information of patient was assessed from medical
records and were analysed and presented as tables and figures.
Background: GBS infection among non-pregnant adults is emerging nowadays. The
severity of the disease caused by GBS depends on the serotype and presence of
virulence genes in the particular strains. This study aimed to determine the distribution
of GBS serotypes and virulence genes and to know the association of GBS serotype
with the clinical disease.
Methods: A cross-sectional study involving retrospective record review was done
involving a total of 75 GBS isolates collected from October 2018 till October 2019 in
two major hospitals in Kelantan (East coast of peninsula Malaysia). Those isolates
were from various clinical samples of non-pregnant adults > 18 years old (excluding
vaginal swab). Identification of all isolates serotype (serotype Ia, Ib, II until IX) and
their virulence genes (scpB, lmb, bca, bac, rib, cylE, and hylE) were done using
conventional PCR. The antibiotic susceptibility testing was traced from The BIOMIC
V3, Microbiology System. Clinical information of patient was assessed from medical
records and were analysed and presented as tables and figures.
Description
Keywords
GBS , non-pregnant