Publication: Correlation of sonographic findings with technetium pertechnetate uptake of thyroid gland in primary hyperthyroid patient
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Date
2022
Authors
Ali, Siti Nur Adni Mohd
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Abstract
Introduction: Radioactive iodine (RAI) has been used since 1941. Despite its long existence and has become a mainstay in treating hyperthyroidism, there’s still debate regarding its dosing method. Technetium pertechnetate thyroid uptake study had been widely used as a preliminary investigation before deciding the actual dose of radioiodine therapy. Besides causing extra radiation to the patient, the technetium pertechnetate thyroid uptake study also caused an additional cost to the patient. Ultrasound has been one of the essential modalities in assessing the thyroid gland. It is a cost-effective, non-radiation study and can determine both the morphological and vascularity status of the thyroid gland. This study aims to determine the correlation of thyroid gland sonographic study (USG) with the value of technetium pertechnetate thyroid scan (TcTU). Methods: A prospective cross-sectional study was conducted in Hospital Universiti Sains Malaysia, Kota Bharu, Kelantan. A total of 17 patients who underwent their TcTU scan for RAI treatment that fulfilled the inclusion and exclusion criteria were included in the study. All patients were subjected to ultrasound prior to the TcTU scan. The subjects’ demographic data were collected and analysed using descriptive analysis and were presented as frequency and percentage. During USG, the thyroid volume (TV-USG) parameter and superior thyroid artery peak systolic velocity (PSV) was recorded, and data were presented as mean and standard deviation. During the TcTU scan, the parameter for TcTU volume (TV-Tc) and TcTU percentage uptakes were recorded, and data were presented as mean and standard deviation. Spearman correlation was used to correlate USG and TcTU findings as the data are not normally distributed. Results: Subjects’ mean age was 41.29 (14.01), with most of the subjects being female (n:12, 70.6%). The mean volume of TV-USG was 34.63 (22.10) ml, and TV-Tc was 43.41 (4.02) ml. The PSV of the thyroid gland was 41.64 (12.81) cm/s, and the percentage of TcTU uptake was 15.58 (12.65) %. There is a strong positive correlation between TV-USG and TV-Tc and a moderate positive correlation between PSV and percentage TcTU uptake (p<0.05). Conclusion: Our study showed a significant positive correlation of volume measurement and a moderate correlation between peak systolic velocity and percentage thyroid uptake between the sonographic findings and the TcTU study. Thus, an ultrasound may play a role in predicting the possible dosage and outcome of the RAI treatment.
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Keywords
Hyperthyroidism , technetium pertechnetate